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CD8\n                      <jats:sup>+<\/jats:sup>\n                      T\u2010cell responses were absent in JME peripheral blood, and in age\u2010 and sex\u2010matched controls. However, CD4\n                      <jats:sup>+<\/jats:sup>\n                      Th1 and Th17 responses were detected in JME peripheral blood versus controls. Cervical LN MNCs from eight of nine JME animals had CD3\n                      <jats:sup>+<\/jats:sup>\n                      T cells specific for MOG, MBP, and PLP that were not detected in controls. Mapping myelin epitopes revealed a heterogeneity in responses among JME animals. Comparison of myelin antigen sequences with those of JM rhadinovirus (JMRV), which is found in JME lesions, identified six viral open reading frames (ORFs) with similarities to myelin antigen sequences. Overlapping peptides to these JMRV ORFs did not induce IFN\n                      <jats:italic>\u03b3<\/jats:italic>\n                      responses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretations<\/jats:title>\n                    <jats:p>\n                      JME possesses an immune\u2010mediated component that involves both CD4\n                      <jats:sup>+<\/jats:sup>\n                      and CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cells specific for myelin antigens. JME may shed new light on inflammatory demyelinating disease pathogenesis linked to gamma\u2010herpesvirus infection.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.51303","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T10:17:41Z","timestamp":1610705861000},"page":"456-470","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Myelin\u2010specific T cells in animals with Japanese macaque encephalomyelitis"],"prefix":"10.1002","volume":"8","author":[{"given":"Aparna N.","family":"Govindan","sequence":"first","affiliation":[{"name":"Vaccine and Gene Therapy Institute Oregon Health &amp; Science University Beaverton OR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8086-5239","authenticated-orcid":false,"given":"Kristin 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