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To identify potential biomarkers, we performed whole\u2010blood RNA sequencing analysis in SMA type 1 subjects under 1\u00a0year old and age\u2010matched healthy controls. Our analysis revealed the\n                    <jats:italic>Heat Shock Protein Family A Member 7 (HSPA7)<\/jats:italic>\n                    \/heat shock 70kDa protein 7 (HSP70B) as a novel candidate biomarker to track SMA progression early in life. Changes in circulating HSP70B protein levels were associated with changes in circulating neurofilament levels in SMA newborns and infants. Future studies will determine whether HSP70B levels respond to molecular therapies.\n                  <\/jats:p>","DOI":"10.1002\/acn3.51377","type":"journal-article","created":{"date-parts":[[2021,5,15]],"date-time":"2021-05-15T05:38:29Z","timestamp":1621057109000},"page":"1495-1501","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Increased systemic HSP70B levels in spinal muscular atrophy infants"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3418-6141","authenticated-orcid":false,"given":"Eric J.","family":"Eichelberger","sequence":"first","affiliation":[{"name":"Department of Neurology Center for Genomic Medicine Massachusetts General Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2646-9689","authenticated-orcid":false,"given":"Christiano R. 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