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However, much remains unknown about its etiology. We performed human leukocyte antigen (HLA) analysis in 82 MOGAD patients of European ancestry in the UK population. No HLA class II associations were observed, thus questioning the mechanism of anti\u2010MOG antibody generation. A weak protective association of <jats:italic>HLA\u2010C*03:04<\/jats:italic> was observed (OR\u00a0=\u00a00.26, 95% CI\u00a0=\u00a00.10\u20100.71, <jats:italic>p<jats:sub>c<\/jats:sub><\/jats:italic>\u00a0=\u00a00.013), suggesting a need for continued efforts to better understand MOGAD genetics and pathophysiology.<\/jats:p>","DOI":"10.1002\/acn3.51378","type":"journal-article","created":{"date-parts":[[2021,5,15]],"date-time":"2021-05-15T17:07:50Z","timestamp":1621098470000},"page":"1502-1507","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["No strong HLA association with MOG antibody disease in the UK population"],"prefix":"10.1002","volume":"8","author":[{"given":"Melissa","family":"Grant\u2010Peters","sequence":"first","affiliation":[{"name":"Nuffield Department of Medicine Wellcome Centre for Human Genetics University of Oxford Oxford 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