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To investigate the molecular mechanisms underlying schwannoma\u2010associated pain we compared the RNA sequencing profile of painful and non\u2010painful schwannomas from NF2 patients. Distinct segregation of painful and non\u2010painful tumors by gene expression patterns was observed. Differential expression analysis showed the upregulation of fibroblast growth factor 7 (FGF7) in painful schwannomas. Behavioral support for this finding was observed using a xenograft human NF2\u2010schwannoma model in nude mice. In this model, over\u2010expression of FGF7 in intra\u2010sciatically implanted NF2 tumor cells generated pain behavior compared with controls.<\/jats:p>","DOI":"10.1002\/acn3.51386","type":"journal-article","created":{"date-parts":[[2021,5,30]],"date-time":"2021-05-30T17:30:50Z","timestamp":1622395850000},"page":"1508-1514","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Transcriptomic signature of painful human neurofibromatosis type 2 schwannomas"],"prefix":"10.1002","volume":"8","author":[{"given":"Phanidhar","family":"Kukutla","sequence":"first","affiliation":[{"name":"Department of Anesthesia, Critical Care, and Pain Medicine Massachusetts General Hospital (MGH) Harvard Medical School (HMS) Boston Massachusetts 02114 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherif G.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Critical Care, and Pain 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