{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:13:22Z","timestamp":1792707202756,"version":"4.5.0"},"reference-count":59,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,7,18]],"date-time":"2021-07-18T00:00:00Z","timestamp":1626566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Traditional posturography measurements characterize postural instability in patients with chemotherapy\u2010induced peripheral neuropathy (CIPN), while underlying postural control mechanisms remain unclear. Taking a model\u2010based approach can yield insights into these mechanisms. This study\u2019s aim was to characterize the modifications in postural control of CIPN patients associated with exercise in relation to the postural behavior of healthy control participants (hCON) via an exploratory approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010one CIPN patients were randomly assigned to two interventions (balance plus moderate endurance training vs. moderate endurance training only) and exercised twice per week over 12\u00a0weeks. Baseline data were compared to 36 matched hCONs. We recorded spontaneous sway and postural reactions to platform tilts using Optotrak and a Kistler force platform pre\u2010 and post\u2010intervention. Data interpretation relied on a model\u2010based parameter identification procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Spontaneous sway amplitudes were larger and postural reactions smaller, with a relative phase advance, in our pre\u2010intervention patients than the hCONs. Post\u2010intervention, spontaneous sway, and postural reactions were reduced and the sensory\u2010motor ratio larger in both groups, while the postural reaction timing differed between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>The abnormally small postural reactions in CIPN patients before the intervention can be interpreted as the consequence of abnormally strong velocity control\u2014a strategy modification that may serve as a prediction mechanism to compensate for the lack of timely and accurate proprioceptive signals. While both groups reduced postural sway and showed an adapted sensory\u2010motor ratio post\u2010intervention, the interventions seemed to trigger different velocity control strategies. This study emphasizes the need for taking a more differentiated perspective on intervention effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial registration<\/jats:title><jats:p>German Clinical Trials Register (DRKS) number: DRKS00005419, prospectively registered on November 19, 2013.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.51426","type":"journal-article","created":{"date-parts":[[2021,7,18]],"date-time":"2021-07-18T15:23:16Z","timestamp":1626621796000},"page":"1680-1694","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Type of exercise may influence postural adaptations in chemotherapy\u2010induced peripheral neuropathy"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8350-8309","authenticated-orcid":false,"given":"Sarah","family":"Waibel","sequence":"first","affiliation":[{"name":"Department of Neurology and Neuroscience Medical Center \u2013 University of Freiburg 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