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We searched the PubMed, EMBASE, Web of Science, Ovid, and Cochrane Library databases for clinical trials of the severity and location of WMHs on the degree of cognitive impairment in PD through October 2020. We conducted the survey to compare the association of WMH burden in patients with PD with mild cognitive impairment (PD\u2010MCI) versus those with normal cognition (PD\u2010NC) and in patients with PD with dementia (PDD) versus those with PD without dementia (PD\u2010ND). Nine studies with PD\u2010MCI versus PD\u2010NC and 10 studies with PDD versus PD\u2010ND comparisons were included. The WMH burden in PD\u2010MCI patients was significantly different compared to that in PD\u2010NC patients (standard mean difference, SMD\u00a0=\u00a00.39, 95% CI: 0.12 to 0.66, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.005), while there was no correlation shown in the age\u2010matched subgroup of the comparison. In addition, PDD patients had a significantly higher burden of WMHs (SMD\u00a0=\u00a00.8, 95% CI: 0.44 to 1.71, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001), especially deep white matter hyperintensities (SMD\u00a0=\u00a00.54, 95% CI: 0.36 to 0.73, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.00001) and periventricular hyperintensities (SMD\u00a0=\u00a00.70, 95% CI: 0.36 to 1.04, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001), than PD\u2010NC patients, regardless of the adjustment of age. WMHs might be imaging markers for cognitive impairment in PDD but not in PD\u2010MCI, regardless of age, vascular risk factors, or race. Further prospective studies are needed to validate the conclusions.<\/jats:p>","DOI":"10.1002\/acn3.51429","type":"journal-article","created":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T15:12:33Z","timestamp":1627312353000},"page":"1917-1934","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["The influence of white matter hyperintensity on cognitive impairment in Parkinson's disease"],"prefix":"10.1002","volume":"8","author":[{"given":"Hailing","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Neurology Zhujiang Hospital of Southern Medical University Guangzhou Guangdong 510282 P.R. 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