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Increasingly, targeted and customized treatment approaches, especially for recurrent disease, are being explored. Here we present a successful outcome in a young patient with rapidly progressive disease who responded to targeted treatment based on genetic sequencing and circulating tumor DNA markers, given the inaccessibility of the tissue to biopsy. Molecular testing on tissue, serum or CSF may be helpful in identifying unique targets in these complex patients.<\/jats:p>","DOI":"10.1002\/acn3.51430","type":"journal-article","created":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T06:54:44Z","timestamp":1627628084000},"page":"1913-1916","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Molecularly targeted treatment of recurrent anaplastic astrocytoma \u2013 a case report"],"prefix":"10.1002","volume":"8","author":[{"given":"Ashna","family":"Yalamanchi","sequence":"first","affiliation":[{"name":"Rosalind Franklin University Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaya Mini","family":"Gill","sequence":"additional","affiliation":[{"name":"Pacific Neuroscience Institute Santa Monica California 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