{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T01:16:20Z","timestamp":1779930980649,"version":"3.53.1"},"reference-count":10,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T00:00:00Z","timestamp":1636502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Female Huntington\u2019s disease (HD) patients have consistently shown a faster clinical worsening than male, but the underlying mechanisms responsible for this observation remain unknown. Here, we describe how sex modifies the impact of neurodegeneration on brain atrophy and clinical severity in HD. Cerebrospinal fluid neurofilament light chain (NfL) levels were used as a biological measure of neurodegeneration, and brain atrophy was assessed by structural magnetic resonance imaging. We found that larger NfL values in women reflect higher brain atrophy and clinical severity than in men (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05 for an interaction model). This differential vulnerability could have important implications in clinical trials.<\/jats:p>","DOI":"10.1002\/acn3.51460","type":"journal-article","created":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T07:52:53Z","timestamp":1636617173000},"page":"2309-2313","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Interaction between sex and neurofilament light chain on brain structure and clinical severity in Huntington\u2019s disease"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3933-1355","authenticated-orcid":false,"given":"Frederic","family":"Sampedro","sequence":"first","affiliation":[{"name":"Movement Disorders Unit Neurology Department Hospital de la Santa Creu i Sant Pau Barcelona Spain"},{"name":"Biomedical Research Institute (IIB\u2010Sant Pau) Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n en Red\u2010Enfermedades Neurodegenerativas (CIBERNED) Barcelona 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