{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T06:10:07Z","timestamp":1781244607155,"version":"3.54.1"},"reference-count":50,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T00:00:00Z","timestamp":1634515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Previous studies have demonstrated that infants are typically born with a <jats:italic>left\u2010greater\u2010than\u2010right<\/jats:italic> forebrain asymmetry that reverses throughout the first year of life. We hypothesized that critically ill term\u2010born and premature patients following surgical and critical care for long\u2010gap esophageal atresia (LGEA) would exhibit alteration in expected forebrain asymmetry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Term\u2010born (<jats:italic>n<\/jats:italic>\u2009=\u200913) and premature (<jats:italic>n<\/jats:italic>\u2009=\u200913) patients, and term\u2010born controls (<jats:italic>n<\/jats:italic>\u2009=\u200923) &lt;1\u2009year corrected age underwent non\u2010sedated research MRI following completion of LGEA treatment via Foker process. Structural T1\u2010 and T2\u2010weighted images were collected, and ITK\u2010SNAP was used for forebrain tissue segmentation and volume acquisition. Data were presented as <jats:italic>absolute<\/jats:italic> (cm<jats:sup>3<\/jats:sup>) and <jats:italic>normalized<\/jats:italic> (% total forebrain) volumes of the hemispheres. All measures were checked for normality, and group status was assessed using a general linear model with age at scan as a covariate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Absolute volumes of both forebrain hemispheres were smaller in term\u2010born and premature patients in comparison to controls (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Normalized hemispheric volume group differences were detected by T1\u2010weighted analysis, with premature patients demonstrating right\u2010greater\u2010than\u2010left hemisphere volumes in comparison to term\u2010born patients and controls (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). While normalized group differences were very subtle (a right hemispheric predominance of roughly 2% of forebrain volume), they represent a deviation from the expected pattern of hemispheric brain asymmetry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Our pilot quantitative MRI study of hemispheric volumes suggests that premature patients might be at risk of altered expected <jats:italic>left\u2010greater\u2010than\u2010right<\/jats:italic> forebrain asymmetry following repair of LGEA. Future neurobehavioral studies in infants born with LGEA are needed to elucidate the functional significance of presented anatomical findings.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.51465","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T08:30:34Z","timestamp":1634805034000},"page":"2132-2145","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Infant study of hemispheric asymmetry after long\u2010gap esophageal atresia repair"],"prefix":"10.1002","volume":"8","author":[{"given":"Mackenzie S.","family":"Kagan","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Critical Care and Pain Medicine Boston Children\u2019s Hospital 300 Longwood Ave. Boston Massachusetts 02115 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandler R. 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