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The quality of life (QoL) underlying the novel PD clinical subtypes is unknown. This study aimed explore the feasibility of the classification in Chinese PD patients and to investigate the potential heterogeneous determinants of QoL among the three subtypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>298 PD patients were enrolled, including 129 PD\u2010MMP patients, 121 PD\u2010IM patients and 48 PD\u2010DM patients. All patients completed the QoL assessment, clinical evaluations and neuropsychological tests. Univariate linear analysis and multiple stepwise regression analysis were performed to identify determinants of QoL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to PD\u2010MMP patients, PD\u2010IM and PD\u2010DM patients had more impaired QoL. The Geriatric Depression Rating Scale (GDS) score, Non\u2010Motor Symptoms Questionnaire (NMSQ) score, Unified Parkinson\u2019s Disease Rating Scale part III (UPDRS\u2010III) score and Epworth Sleepiness Score (ESS) were independent contributors to QoL in PD\u2010MMP patients. The GDS score, ESS and sniffin\u2019 sticks screening 12 test score were independent contributors to QoL in PD\u2010IM patients. The GDS score and Mini Mental State Examination score were independent contributors to QoL in PD\u2010DM patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>The new novel subtyping classification is feasible for Chinese PD patients. Although depression was the most crucial determinant for QoL in PD\u2010MMP, PD\u2010IM and PD\u2010DM patients, the other contributors of QoL in the three subtypes were heterogeneous. These findings may prompt clinicians to target specific factors for improving QoL depending on PD subtypes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.51475","type":"journal-article","created":{"date-parts":[[2021,10,30]],"date-time":"2021-10-30T09:28:54Z","timestamp":1635586134000},"page":"2174-2183","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Determinants of quality of life in Parkinson\u2019s disease: a perspective of novel clinical subtypes"],"prefix":"10.1002","volume":"8","author":[{"given":"Yun","family":"Fan","sequence":"first","affiliation":[{"name":"Department of Neurology and National Research Center for Aging and Medicine &amp; National Center for Neurological Disorders State Key Laboratory of Medical Neurobiology Huashan Hospital Fudan University Shanghai 200040 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