{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:12:30Z","timestamp":1790435550354,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This long\u2010term retrospective follow\u2010up study aimed to address the knowledge gap between prenatal diagnosis of complete isolated Agenesis of Corpus Callosum (cACC) at fetal MRI and postnatal neurodevelopmental outcome to improve prenatal counseling for parents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data on fetuses with isolated cACC from a single\u2010center MRI database built up in two decades were considered. Detailed postnatal clinical, neuropsychological evaluations were performed and descriptions of available neuroradiological and genetic data were provided.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Following a detailed neuropsychological evaluation and a long\u2010term follow\u2010up, the subsequent results emerged: 38 school\u2010aged children (older than 6\u2009years) of 50 (aged 2.5\u201015\u2009years) showed normal intellectual functions (50%), intellectual disability (21%), and borderline intelligence quotient (29%). Deficits in motor functions (58%), executive functions (37%), language (61%), memory abilities (58%), and academic performances (53%) were found. Twenty\u2010one percent of participants showed behavioral difficulties. Almost half of the participants underwent rehabilitation. Additional findings (21%) were detected at postnatal brain MRI, and a significant association between additional findings at postnatal imaging and abnormal neurodevelopmental outcome was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretations<\/jats:title><jats:p>This study supports the view that children with prenatal diagnosis of isolated cACC may present with several degrees of neurologic and neuropsychological impairment which become more evident only in their second decade of life. Postnatal MRI and detailed genetic analysis may add crucial information to prenatal data and substantially influence final judgment on the outcome and orient clinical management and counseling.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.51484","type":"journal-article","created":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T09:58:40Z","timestamp":1638352720000},"page":"2280-2288","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Long\u2010term follow\u2010up in a cohort of children with isolated corpus callosum agenesis at fetal MRI"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8709-6732","authenticated-orcid":false,"given":"Romina","family":"Romaniello","sequence":"first","affiliation":[{"name":"Neuropsychiatry and Neurorehabilitation Unit Scientific Institute IRCCS Eugenio Medea Bosisio Parini Lecco Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Arrigoni","sequence":"additional","affiliation":[{"name":"Neuroimaging Lab Scientific Institute IRCCS Eugenio Medea Bosisio Parini Lecco Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"De Salvo","sequence":"additional","affiliation":[{"name":"Neuropsychiatry and Neurorehabilitation Unit Scientific Institute IRCCS Eugenio Medea Bosisio Parini Lecco Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Clara","family":"Bonaglia","sequence":"additional","affiliation":[{"name":"Cytogenetics Laboratory Scientific Institute IRCCS Eugenio Medea Bosisio Parini Lecco Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Panzeri","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology Scientific Institute IRCCS Eugenio Medea Bosisio Parini Lecco Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"Bassi","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology Scientific Institute IRCCS Eugenio Medea Bosisio Parini Lecco Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Parazzini","sequence":"additional","affiliation":[{"name":"Radiology and Neuroradiology Department Children\u2019s Hospital V. 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