{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T08:01:44Z","timestamp":1792483304284,"version":"4.5.0"},"reference-count":75,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100002582","name":"American Geriatrics Society","doi-asserted-by":"publisher","award":["Jahnigen Scholars Fellowship"],"award-info":[{"award-number":["Jahnigen Scholars Fellowship"]}],"id":[{"id":"10.13039\/100002582","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005831","name":"Foundation for Anesthesia Education and Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005831","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR002553\u201002"],"award-info":[{"award-number":["UL1TR002553\u201002"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UH2 AG056925\u201002"],"award-info":[{"award-number":["UH2 AG056925\u201002"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01\u2010AG042599"],"award-info":[{"award-number":["R01\u2010AG042599"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01\u2010HL130443"],"award-info":[{"award-number":["R01\u2010HL130443"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01\u2010HL088942"],"award-info":[{"award-number":["U01\u2010HL088942"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K76\u2010AG057022"],"award-info":[{"award-number":["K76\u2010AG057022"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30\u2010AG028716"],"award-info":[{"award-number":["P30\u2010AG028716"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM08600"],"award-info":[{"award-number":["GM08600"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R03 AG050918"],"award-info":[{"award-number":["R03 AG050918"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Numerous investigators have theorized that postoperative changes in Alzheimer's disease neuropathology may underlie postoperative neurocognitive disorders. Thus, we determined the relationship between postoperative changes in cognition and cerebrospinal (\n                      <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>\n                      ) tau, p\u2010tau\u2010181p, or A\u03b2 levels after non\u2010cardiac, non\u2010neurologic surgery in older adults.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants underwent cognitive testing before and 6\u2009weeks after surgery, and lumbar punctures before, 24\u2009h after, and 6\u2009weeks after surgery. Cognitive scores were combined via factor analysis into an overall cognitive index. In total, 110 patients returned for 6\u2010week postoperative testing and were included in the analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There was no significant change from before to 24\u2009h or 6\u2009weeks following surgery in CSF tau (median [median absolute deviation] change before to 24\u2009h: 0.00 [4.36] pg\/mL,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.853; change before to 6\u2009weeks: \u22121.21 [3.98] pg\/mL,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.827). There were also no significant changes in CSF p\u2010tau\u2010181p or A\u03b2 over this period. There was no change in cognitive index (mean [95% CI] 0.040 [\u22120.018, 0.098],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.175) from before to 6\u2009weeks after surgery, although there were postoperative declines in verbal memory (\u22120.346 [\u22120.523, \u22120.170],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003) and improvements in executive function (0.394, [0.310, 0.479],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). There were no significant correlations between preoperative to 6\u2010week postoperative changes in cognition and CSF tau, p\u2010tau\u2010181p, or A\u03b242 changes over this interval (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05 for each).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Neurocognitive changes after non\u2010cardiac, non\u2010neurologic surgery in the majority of cognitively healthy, community\u2010dwelling older adults are unlikely to be related to postoperative changes in AD neuropathology (as assessed by CSF A\u03b2, tau or p\u2010tau\u2010181p levels or the p\u2010tau\u2010181p\/A\u03b2 or tau\/A\u03b2 ratios).<\/jats:p>\n                    <jats:p>\n                      Trial Registration:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">clinicaltrials.gov<\/jats:ext-link>\n                      (NCT01993836).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.51499","type":"journal-article","created":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T09:40:34Z","timestamp":1643708434000},"page":"155-170","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Postoperative changes in cognition and cerebrospinal fluid neurodegenerative disease biomarkers"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2386-5061","authenticated-orcid":false,"given":"Miles","family":"Berger","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Duke University Medical Center  Durham North Carolina USA"},{"name":"Center for the Study of Aging and Human Development Duke University Medical Center  Durham North Carolina USA"},{"name":"Center for Cognitive Neuroscience Duke University  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey N.","family":"Browndyke","sequence":"additional","affiliation":[{"name":"Center for the Study of Aging and Human Development Duke University Medical Center  Durham North Carolina USA"},{"name":"Center for Cognitive Neuroscience Duke University  Durham North Carolina USA"},{"name":"Division of Geriatric Behavioral Health, Department of Psychiatry and Behavioral Medicine Duke University Medical Center  Durham North Carolina USA"},{"name":"Duke Brain Imaging and Analysis Center  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Cooter Wright","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Duke University Medical Center  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2475-6577","authenticated-orcid":false,"given":"Chloe","family":"Nobuhara","sequence":"additional","affiliation":[{"name":"Duke University School of Medicine  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8288-7914","authenticated-orcid":false,"given":"Melody","family":"Reese","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Duke University Medical Center  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah","family":"Acker","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Duke University Medical Center  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Michael","family":"Bullock","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Duke University Medical Center  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J.","family":"Colin","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Duke University Medical Center  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Devinney","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Duke University Medical Center  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene W.","family":"Moretti","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Duke University Medical Center  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judd W.","family":"Moul","sequence":"additional","affiliation":[{"name":"Urology Division, Department of Surgery Duke University Medical Center  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Ohlendorf","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Duke University Medical Center  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel T.","family":"Laskowitz","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Duke University Medical Center  Durham North Carolina USA"},{"name":"Department of Neurology Duke University Medical Center  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Waligorska","sequence":"additional","affiliation":[{"name":"Department of Pathology and Lab Medicine, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie M.","family":"Shaw","sequence":"additional","affiliation":[{"name":"Department of Pathology and Lab Medicine, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather E.","family":"Whitson","sequence":"additional","affiliation":[{"name":"Center for the Study of Aging and Human Development Duke University Medical Center  Durham North Carolina USA"},{"name":"Department of Medicine Duke University Medical Center  Durham North Carolina USA"},{"name":"Geriatrics Research Education and Clinical Center (GRECC) Durham VA Medical Center  Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harvey J.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Center for the Study of Aging and Human Development Duke University Medical Center  Durham North Carolina USA"},{"name":"Department of Medicine Duke University Medical Center  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph P.","family":"Mathew","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Duke University Medical Center  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the MADCO\u2010PC Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/2151458510394606"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12328"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2013.05.1766"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.112.119610"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3181bc9719"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.2007.19.1.21"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2013.01.024"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s100720200017"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002093-200307000-00003"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000953"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2017.11.087"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200102083440601"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.03.005"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21382"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2009.04.061"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.14534"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23898"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20160"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2019.08.024"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e318246ec0b"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200409000-00019"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21548"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e31824be8c7"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-122424"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2015.05.002"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016648"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181f17bcb"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0b013e3283534f56"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e31822e9306"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-151190"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-100702"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2012.04.044"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2012.02769.x"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2014.00047"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)00070-3"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0b013e3181c15c70"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-020-09797-1"},{"key":"e_1_2_9_39_1","first-page":"698","article-title":"Derivation of cutoffs for the Elecsys((R)) amyloid beta (1\u201042) assay in Alzheimer's disease","volume":"10","author":"Shaw LM","year":"2018","journal-title":"Alzheimers Dement"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v045.i06"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3181d31fd7"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(01)00297-2"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.003"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21610"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e31828ce55d"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2020.08.061"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2020.09.043"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e31816c902a"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1090-3801(97)90069-0"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-019-0157-2"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.178.4.360"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000004179"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000002194"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000002338"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000002668"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000002103"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1112923"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-201544"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.531236"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.anes.0000281896.07256.71"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.01.080"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.002703"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1177\/0267659112453475"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)07382-0"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.anes.0000296071.19434.1e"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aet420"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2007.06.023"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aet055"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.11.1405"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.56"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2017.04.013"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.680912"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acr120"},{"key":"e_1_2_9_76_1","volume-title":"Fundamentals of Biostatistics","author":"Rosner B","year":"2006"}],"container-title":["Annals of Clinical and Translational Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.51499","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acn3.51499","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.51499","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,26]],"date-time":"2023-08-26T22:18:10Z","timestamp":1693088290000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/acn3.51499"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":75,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1002\/acn3.51499"],"URL":"https:\/\/doi.org\/10.1002\/acn3.51499","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.741586082.793591508","asserted-by":"object"}]},"ISSN":["2328-9503","2328-9503"],"issn-type":[{"value":"2328-9503","type":"print"},{"value":"2328-9503","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"2021-11-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}