{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T03:33:13Z","timestamp":1770521593293,"version":"3.49.0"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T00:00:00Z","timestamp":1645488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005614","name":"Biogen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005614","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005624","name":"Medizinischen Hochschule Hannover","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005624","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005930","name":"ASCRS Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005930","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Fatigue is a common and burdensome symptom of spinal muscular atrophy. Given its complex interactions, different dimensions of fatigue need to be investigated. The Multidimensional Fatigue Inventory is a widely used instrument that captures five distinct dimensions. The aim of this study was to investigate the validity and reliability of the German Multidimensional Fatigue Inventory in spinal muscular atrophy and to evaluate the presence of clinically relevant fatigue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and forty adult spinal muscular atrophy patients completed the Multidimensional Fatigue Inventory in a nationwide, multicenter, cross\u2010sectional study. Structural validity was explored using principal component analysis. Cronbach\u2019s \u03b1 was calculated to evaluate internal consistency. Convergent validity was assessed by correlation with a Visual Analog Scale for fatigue and the EuroQol\u2010Five Dimension\u2010Five Level Scale as a measure of quality of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The original five\u2010component model of the questionnaire constituted an acceptable fit. Internal consistency and convergent validity of <jats:italic>general<\/jats:italic>, <jats:italic>physical<\/jats:italic>, <jats:italic>mental fatigue<\/jats:italic>, and <jats:italic>reduced activity<\/jats:italic> were good. We observed a floor effect for <jats:italic>mental fatigue<\/jats:italic>. While <jats:italic>physical fatigue<\/jats:italic> exceeded the cutoff for clinically relevant fatigue, all dimensions but <jats:italic>reduced motivation<\/jats:italic> correlated negatively with quality of life. Age, depression, and \u22654 copies of the <jats:italic>survival motor neuron 2<\/jats:italic> gene were associated with higher <jats:italic>general\/physical fatigue<\/jats:italic>; unemployed participants reported higher scores for <jats:italic>reduced activity\/motivation<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>The Multidimensional Fatigue Inventory is a valid and reliable instrument to assess different dimensions of fatigue in spinal muscular atrophy. Fatigue is a relevant problem in spinal muscular atrophy and its assessment should be incorporated into standard care.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.51520","type":"journal-article","created":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T13:04:13Z","timestamp":1645535053000},"page":"351-362","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Validity and reliability of the German multidimensional fatigue inventory in spinal muscular atrophy"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3035-4638","authenticated-orcid":false,"given":"Camilla","family":"Binz","sequence":"first","affiliation":[{"name":"Department of Neurology Hannover Medical School Hanover 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