{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:42:43Z","timestamp":1792154563083,"version":"4.4.0"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T00:00:00Z","timestamp":1646870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Medical cannabis formulations with cannabidiol (CBD) and delta\u20109\u2010tetrahydrocannabinol (THC) are widely used to treat epilepsy. We studied the safety and efficacy of two formulations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively observed 29 subjects (12 to 46\u2009years old) with treatment\u2010resistant epilepsies (11 Lennox\u2013Gastaut syndrome; 15 with focal or multifocal epilepsy; three generalized epilepsy) were treated with medical cannabis (1THC:20CBD and\/or 1THC:50CBD; maximum of 6\u2009mg THC\/day) for \u226524\u2009weeks. The primary outcome was change in convulsive seizure frequency from the pre\u2010treatment baseline to the stable optimal dose phase.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no significant differences during treatment on stable maximal doses for convulsive seizure frequency, seizure duration, postictal duration, or use of rescue medications compared to baseline. No benefits were seen for behavioral disorders or sleep duration; there was a trend for more frequent bowel movements compared to baseline. Ten adverse events occurred in 6\/29 patients, all were transient and most unrelated to study medication. No serious adverse events were related to study medication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Our prospective observational study of two high\u2010CBD\/low\u2010THC formulations found no evidence of efficacy in reducing seizures, seizure duration, postictal duration, or rescue medication use. Behavioral disorders or sleep duration was unchanged. Study medication was generally well tolerated. The doses of CBD used were lower than prior studies. Randomized trials with larger cohorts are needed, but we found no evidence of efficacy for two CBD:THC products in treating epilepsy, sleep, or behavior in our population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.51537","type":"journal-article","created":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T13:48:35Z","timestamp":1646920115000},"page":"497-505","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Observational study of medical marijuana as a treatment for <scp>treatment\u2010resistant<\/scp> epilepsies"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0044-4632","authenticated-orcid":false,"given":"Orrin","family":"Devinsky","sequence":"first","affiliation":[{"name":"NYU Comprehensive Epilepsy Center New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelica","family":"Marmanillo","sequence":"additional","affiliation":[{"name":"The Center for Discovery Harris New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"Hamlin","sequence":"additional","affiliation":[{"name":"The Center for Discovery Harris New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Wilken","sequence":"additional","affiliation":[{"name":"The Center for Discovery Harris New York USA"},{"name":"Crystal Run Healthcare Rock Hill New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Ryan","sequence":"additional","affiliation":[{"name":"The Center for Discovery Harris New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conor","family":"Anderson","sequence":"additional","affiliation":[{"name":"The Center for Discovery Harris New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Friedman","sequence":"additional","affiliation":[{"name":"NYU Comprehensive Epilepsy Center New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Todd","sequence":"additional","affiliation":[{"name":"The Center for Discovery Harris New York USA"},{"name":"Icahn School of Medicine at Mount Sinai New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.5698\/1535\u20107511\u201012.4.131"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(16)30158\u20102"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1407304"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2016.11.012"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1611618"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.621"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.4607"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13345"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16973"},{"key":"e_1_2_8_11_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2020"},{"key":"e_1_2_8_12_1","volume-title":"RStudio: Integrated Development Environment for R","author":"RStudio Team","year":"2020"},{"key":"e_1_2_8_13_1","unstructured":"Wickham H. 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Henry L. &M\u00fcller K.(2020).Dplyr: a grammar of data manipulation.https:\/\/CRAN.R\u2010project.org\/package=dplyr."},{"key":"e_1_2_8_14_1","unstructured":"Wickham H. &Henry L.(2020).tidyr: Tidy Messy Data.https:\/\/CRAN.R\u2010project.org\/package=tidyr\\."},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-24277-4"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/can.2020"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1714631"}],"container-title":["Annals of Clinical and Translational Neurology"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.51537","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acn3.51537","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.51537","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T09:09:33Z","timestamp":1692954573000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/acn3.51537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,10]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1002\/acn3.51537"],"URL":"https:\/\/doi.org\/10.1002\/acn3.51537","archive":["Portico"],"relation":{},"ISSN":["2328-9503","2328-9503"],"issn-type":[{"value":"2328-9503","type":"print"},{"value":"2328-9503","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,10]]},"assertion":[{"value":"2021-11-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}