{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:51:04Z","timestamp":1787500264407,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T00:00:00Z","timestamp":1662508800000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["4U10NS077260\u201007"],"award-info":[{"award-number":["4U10NS077260\u201007"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Positron emission tomography with fluorine\u201018 fluorodeoxyglucose (\n                    <jats:sup>18<\/jats:sup>\n                    F\u2010FDG\u2010PET) has been used over 3 decades to map patterns of brain glucose metabolism to evaluate normal brain function or demonstrate abnormalities of metabolism in brain disorders. Traditional PET maps patterns of absolute tracer uptake but has demonstrated shortcomings in disorders such as brain neoplasm or focal epilepsy in the ability to resolve normally from pathological tissue. In this review, we describe an alternative process of metabolic mapping, dynamic PET. This new technology quantifies the dynamics of tracer uptake and decays with the goal of improving the functional mapping of the desired metabolic activity in the target organ. We discuss technical implementation and findings of initial pilot studies in brain tumor treatment and epilepsy surgery.\n                  <\/jats:p>","DOI":"10.1002\/acn3.51546","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T03:25:40Z","timestamp":1662521140000},"page":"1487-1497","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Dynamic\n                    <scp>FDG\u2010PET<\/scp>\n                    demonstration of functional brain abnormalities"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3035-9260","authenticated-orcid":false,"given":"Mark","family":"Quigg","sequence":"first","affiliation":[{"name":"Department of Neurology University of Virginia  Charlottesville Virginia 22908 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bijoy","family":"Kundu","sequence":"additional","affiliation":[{"name":"Departments of Radiology &amp; Medical Imaging and Biomedical Engineering University of Virginia  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31821527b5"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2009.07.002"},{"issue":"5","key":"e_1_2_12_4_1","first-page":"13","article-title":"FDG\u2010PET imaging in mild traumatic brain injury: a critical review","volume":"9","author":"Byrnes KR","year":"2014","journal-title":"Front Neuroenergetics"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.07.2660"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNM.0000000000000753"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-199605000-00003"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2014.06.012"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2016161172"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2021.108204"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410060502"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nucmedbio.2005.06.012"},{"issue":"16","key":"e_1_2_12_13_1","doi-asserted-by":"crossref","first-page":"165010","DOI":"10.1088\/1361-6560\/ab3238","article-title":"Non\u2010invasive determination of blood input function to compute rate of myocardial glucose uptake from dynamic FDG PET images of rat heart in\u00a0vivo: comparative study between the inferior vena cava and the left ventricular blood pool with spill over and partial volume corrections","volume":"64","author":"Huang Q","year":"2019","journal-title":"Phys Med Biol"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1109\/TNS.2013.2269032"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.618645"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40336-019-00316-5"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1996.0066"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2014.261"},{"key":"e_1_2_12_19_1","first-page":"427","article-title":"Dynamic FDG brain PET imaging using Helmet_PET: model corrected blood input function to compute FDG uptake rate during an ambulatory upright task","volume":"59","author":"Huang Q","year":"2018","journal-title":"J Nucl Med"},{"key":"e_1_2_12_20_1","first-page":"A7","article-title":"Total body dynamic FDG PET imaging of spontaneously hypertensive rats","volume":"5","author":"Huang Q","year":"2018","journal-title":"EJNMMI Phys"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.010926"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867324666170516123206"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-013-2396-9"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0b013e31820a9eea"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.neu.0000316018.51292.19"},{"issue":"6","key":"e_1_2_12_26_1","first-page":"904","article-title":"18F\u2010FDOPA PET imaging of brain tumors: comparison study with 18F\u2010FDG PET and evaluation of diagnostic accuracy","volume":"47","author":"Chen W","year":"2006","journal-title":"J Nucl Med"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nov148"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.119.234757"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.2310\/7290.2014.00015"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/now058"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.119.233809"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-013-2678-2"},{"key":"e_1_2_12_33_1","volume-title":"Parametric FDG PET Quantification,Segmentation and Classification of Primary Brain Tumors in Human GBM [abstract]","author":"Schetlick RS","year":"2021"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200002033420503"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000055086.35806.2D"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2010.02.007"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00993"},{"key":"e_1_2_12_38_1","first-page":"116","article-title":"MRtrix3: a fast, flexible and open software framework for medical im\u2010age processing and visualisation. 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