{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T22:39:19Z","timestamp":1769726359515,"version":"3.49.0"},"reference-count":55,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T00:00:00Z","timestamp":1652832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To disclose the nature of cognitive deficits in a cohort of patients with idiopathic autonomic failure (IAF) by exploring the relation among cognitive functions, cardiovascular autonomic failure (AF) and clinical progression to another \u03b1\u2010synucleinopathy (phenoconversion).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively identified all patients with a clinical diagnosis of IAF who underwent a comprehensive neuropsychological evaluation, clinical examination and cardiovascular autonomic tests from the IAF\u2010BO cohort. Brain magnetic resonance imaging (MRI) studies and cerebrospinal fluid (CSF) analysis, including neurofilament light chain (NfL), Alzheimer disease core biomarkers, and \u03b1\u2010synuclein seeding activity were further evaluated when available.<\/jats:p><jats:p>Correlations among cognitive functions, clinical features, cardiovascular AF, cerebral white matter hyperintensities (WMH) load, and CSF biomarkers were estimated using Spearman correlation coefficient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen out of 30 (43%) patients with IAF displayed cognitive deficits (CI) mainly concerning executive functioning. Seven out of 30 (23%) met the criteria for mild cognitive impairment (MCI).<\/jats:p><jats:p>The diagnosis of CI and MCI was not associated with phenoconversion or autonomic function parameters, including duration and severity of neurogenic orthostatic hypotension, presence and severity of supine hypertension, and nocturnal dipper profile.<\/jats:p><jats:p>Twenty patients underwent a brain MRI and CSF analysis. MCI was related to WMH load (<jats:italic>r<\/jats:italic>\u2009=\u20090.549) and NfL levels (<jats:italic>r<\/jats:italic>\u2009=\u20090.656), while autonomic function parameters were not associated with either WMH or NfL levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Cardiovascular AF and phenoconversion, underlying the spreading of neurodegeneration to the central nervous system, were not independent drivers of cognitive dysfunction in IAF. We identified WMH load and NfL levels as potential biomarkers of the neural network disruption associated with cognitive impairment in patients with IAF.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.51567","type":"journal-article","created":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T08:51:45Z","timestamp":1652863905000},"page":"864-876","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cognitive profile in idiopathic autonomic failure: relation with white matter hyperintensities and neurofilament levels"],"prefix":"10.1002","volume":"9","author":[{"given":"Ilaria","family":"Cani","sequence":"first","affiliation":[{"name":"Department of Biomedical and NeuroMotor Sciences (DIBINEM) Alma Mater Studiorum \u2010 University of Bologna Bologna Italy"},{"name":"IRCCS Istituto delle Scienze Neurologiche di Bologna Via Altura, 3 40139 Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Sambati","sequence":"additional","affiliation":[{"name":"IRCCS Istituto delle Scienze Neurologiche di Bologna Via Altura, 3 40139 Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiorina","family":"Bartiromo","sequence":"additional","affiliation":[{"name":"IRCCS Istituto delle Scienze Neurologiche di Bologna Via Altura, 3 40139 Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gian Maria","family":"Asioli","sequence":"additional","affiliation":[{"name":"Department of Biomedical and NeuroMotor Sciences (DIBINEM) Alma Mater Studiorum \u2010 University of Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Baiardi","sequence":"additional","affiliation":[{"name":"IRCCS Istituto delle Scienze Neurologiche di Bologna Via Altura, 3 40139 Bologna Italy"},{"name":"Department of Experimental Diagnostic and Specialty Medicine (DIMES), Alma Mater Studiorum \u2010 University of Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura M. 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