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We first performed a Genomewide Association Study (GWAS) for ICDs anytime during PD in 5262 PD individuals from the 23andMe cohort. We then combined newly discovered ICD risk loci with 13 ICD risk loci previously reported in the literature to develop a model predicting ICD in a Training dataset (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009339, from UPenn and PPMI cohorts). The model was tested in a non\u2010overlapping Test dataset (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009169, from UPenn and PPMI cohorts) and used to derive a continuous measure, the ICD\u2010risk score (ICD\u2010RS), enriching for PD individuals with ICD (ICD+ PD).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      By GWAS, we discovered four new loci associated with ICD at\n                      <jats:italic>p<\/jats:italic>\n                      \u2010values of 4.9e\u201007 to 1.3e\u201006\n                      <jats:sub>.<\/jats:sub>\n                      Our best logistic regression model included seven clinical and two genetic variables, achieving an area under the receiver operating curve for ICD prediction of 0.75 in the Training and 0.72 in the Test dataset. The ICD\u2010RS separated groups of PD individuals with ICD prevalence of nearly 40% (highest risk quartile) versus 7% (lowest risk quartile).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>In this multi\u2010cohort, international study, we developed an easily computed clinico\u2010genetic tool, the ICD\u2010RS, that substantially enriches for subgroups of PD at very high versus very low risk for ICD, enabling pharmacogenetic approaches to PD medication selection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.51569","type":"journal-article","created":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T02:41:06Z","timestamp":1656384066000},"page":"936-949","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Genetic prediction of impulse control disorders in Parkinson's disease"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0633-7168","authenticated-orcid":false,"given":"Daniel","family":"Weintraub","sequence":"first","affiliation":[{"name":"Department of Psychiatry Perelman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Department of Neurology Perelman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Parkinson\u2019s Disease Research, Education and Clinical Center (PADRECC) Philadelphia Veterans Affairs Medical Center  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marijan","family":"Posavi","sequence":"additional","affiliation":[{"name":"Department of Neurology Perelman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Fontanillas","sequence":"additional","affiliation":[{"name":"23andMe  Sunnyvale California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0766-1496","authenticated-orcid":false,"given":"Thomas F.","family":"Tropea","sequence":"additional","affiliation":[{"name":"Department of Neurology Perelman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenia","family":"Mamikonyan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Perelman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunran","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Perelman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Q.","family":"Trojanowski","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Perelman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Cannon","sequence":"additional","affiliation":[{"name":"23andMe  Sunnyvale California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivianna M.","family":"Van Deerlin","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Perelman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"23andMe Research 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