{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T07:44:09Z","timestamp":1780991049461,"version":"3.54.1"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T00:00:00Z","timestamp":1655251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the initial features and evolution of neurologic Postacute Sequelae of SARS\u2010CoV\u20102 infection (neuro\u2010PASC) in patients with and without prior neurologic disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants with neurologic symptoms following acute SARS\u2010CoV\u20102 infection were recruited from October 9, 2020 to October 11, 2021. Clinical data included a SARS\u2010CoV\u20102 infection history, neurologic review of systems, neurologic exam, Montreal cognitive assessment (MoCA), and symptom\u2010based self\u2010reported surveys at baseline (conducted after acute infection) and 6\u2010month follow\u2010up assessments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010six participants (69% female, mean age 50\u2009years, 29% with prior neurologic disease such as multiple sclerosis) were enrolled, of which 27 had completed the 6\u2010month follow\u2010up visit in this ongoing study. SARS\u2010CoV\u20102 infection severity was largely described as mild (39.3%) or moderate (42.9%). At baseline, following acute infection, the most common neurologic symptoms were fatigue (89.3%) and headaches (80.4%). At the 6\u2010month follow\u2010up, memory impairment (68.8%) and decreased concentration (61.5%) were the most prevalent, though on average all symptoms showed a reduction in reported severity score at the follow\u2010up. Complete symptom resolution was reported in 33.3% of participants by 6 months<jats:italic>.<\/jats:italic> From baseline to 6 months, average MoCA scores improved overall though 26.3% of participants\u2019 scores decreased. A syndrome consisting of tremor, ataxia, and cognitive dysfunction (PASC\u2010TAC) was observed in 7.1% of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Early in the neuro\u2010PASC syndrome, fatigue and headache are the most commonly reported symptoms. At 6 months, memory impairment and decreased concentration were most prominent. Only one\u2010third of participants had completed resolution of neuro\u2010PASC at 6 months, although persistent symptoms trended toward improvement at follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.51578","type":"journal-article","created":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T07:40:42Z","timestamp":1655278842000},"page":"995-1010","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Longitudinal evaluation of <scp>neurologic\u2010post<\/scp> acute sequelae <scp>SARS\u2010CoV<\/scp>\u20102 infection symptoms"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5079-9223","authenticated-orcid":false,"given":"Jacqueline E.","family":"Shanley","sequence":"first","affiliation":[{"name":"Department of Neurosciences University of California, San Diego  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew 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