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We show that bexarotene, a putatively remyelinating retinoid\u2010X receptor agonist, shortened the visual evoked potential latency in patients with chronic optic neuropathy aged under 42\u2009years only (with the effect diminishing by 0.45\u2009ms per year of age); and increased the magnetization transfer ratio of deep gray matter lesions in those under 43\u2009years only. Addressing this age\u2010related decline in human remyelination capacity will be an important step in the development of remyelinating therapies that work across the lifespan.<\/jats:p>","DOI":"10.1002\/acn3.51595","type":"journal-article","created":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T15:22:16Z","timestamp":1652973736000},"page":"1090-1094","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Remyelination in humans due to a retinoid\u2010X receptor agonist is age\u2010dependent"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8710-0930","authenticated-orcid":false,"given":"Christopher E.","family":"McMurran","sequence":"first","affiliation":[{"name":"Department of Clinical Neurosciences University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trisha","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7737-5834","authenticated-orcid":false,"given":"J William L.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences University of Cambridge  Cambridge UK"},{"name":"NMR Research Unit, Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation University College London (UCL) Queen Square Institute of Neurology  London UK"},{"name":"Clinical Outcomes Research Unit (CORe) University of Melbourne  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew W.","family":"Michell","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Declan T.","family":"Chard","sequence":"additional","affiliation":[{"name":"NMR Research Unit, Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation University College London (UCL) Queen Square Institute of Neurology  London UK"},{"name":"National Institute for Health Research (NIHR) University College London Hospitals (UCLH) Biomedical Research Centre  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin J. 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