{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:50:53Z","timestamp":1787763053794,"version":"build-2784847793"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,6,4]],"date-time":"2022-06-04T00:00:00Z","timestamp":1654300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7194323"],"award-info":[{"award-number":["7194323"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The present study was intended to analyze the characteristics of myelinated nerve fibers density (MFD) of transthyretin amyloid polyneuropathy (ATTR\u2010PN) and other similar neuropathies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 41 patients with ATTR\u2010PN, 58 patients of other common peripheral neuropathies, and 17 age\u2010and gender\u2010matched controls who visited the First Hospital of Peking University and performed sural nerve biopsy between June 2007 and August 2021 were included for analysis of MFD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Except the vasculitic neuropathy group, the total and small MFD of patients in the ATTR\u2010PN group were significantly lower than those of other disease groups. There was an obvious negative correlation between the total MFD and the disease course in the ATTR\u2010PN group. The disease course of early\u2010onset and late\u2010onset symptoms was similar, but the loss of large myelinated nerve fibers (MF) was more severe for the latter. In addition, all late\u2010onset and most early\u2010onset patients had severely reduced MFD after a 2\u2009years' disease course. The MFD in ATTR\u2010PN patients was negatively correlated with Neuropathy Impairment Score (NIS) and Norfolk Quality of life\u2010diabetic neuropathy (Norfolk QOL\u2010DN) score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MF\u2009is lost differently in ATTR\u2010PN and in other common peripheral neuropathies. The late\u2010onset and early\u2010onset ATTR\u2010PN patients have different patterns of loss of large and small MF.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.51599","type":"journal-article","created":{"date-parts":[[2022,6,5]],"date-time":"2022-06-05T03:54:40Z","timestamp":1654401280000},"page":"1059-1068","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Patterns of myelinated nerve fibers loss in transthyretin amyloid polyneuropathy and mimics"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3088-8552","authenticated-orcid":false,"given":"Kang","family":"Du","sequence":"first","affiliation":[{"name":"Department of Neurology Peking University First Hospital  8 Xishiku Street, Xicheng District Beijing 100034 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xujun","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Neurology Peking 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