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Some may harbor previously undetected structural variants (SVs) or cryptic splice sites. We enrolled 10 unrelated families: nine had muscular dystrophy but lacked complete genetic diagnoses and one had an asymptomatic <jats:italic>DMD<\/jats:italic> duplication. Nanopore genomic long\u2010read sequencing identified previously undetected pathogenic variants in four individuals: an SV in <jats:italic>DMD<\/jats:italic>, an SV in <jats:italic>LAMA2<\/jats:italic>, and two single nucleotide variants in <jats:italic>DMD<\/jats:italic> that alter splicing. The DMD duplication in the asymptomatic individual was in tandem. Nanopore sequencing may help streamline genetic diagnostic approaches for muscular dystrophy.<\/jats:p>","DOI":"10.1002\/acn3.51612","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T09:01:42Z","timestamp":1655974902000},"page":"1302-1309","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Diagnostic capabilities of nanopore long\u2010read sequencing in muscular dystrophy"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8366-3691","authenticated-orcid":false,"given":"Christine C.","family":"Bruels","sequence":"first","affiliation":[{"name":"Paul and Sheila Wellstone Muscular Dystrophy Center and Department of Neurology University of Minnesota Medical School  Minneapolis Minnesota 55455"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah R.","family":"Littel","sequence":"additional","affiliation":[{"name":"Paul and Sheila 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