{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T14:47:34Z","timestamp":1792853254365,"version":"4.5.0"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T00:00:00Z","timestamp":1655769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005156","name":"Alexander von Humboldt-Stiftung","doi-asserted-by":"publisher","award":["739510"],"award-info":[{"award-number":["739510"]}],"id":[{"id":"10.13039\/100005156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>CAG repeat\u2010expansion spinocerebellar ataxias (CAG\u2010SCAs) are genetically defined multisystemic degenerative diseases, resulting in motor symptoms including dysarthria with a substantial impact on daily living. Whilst speech therapy is widely recommended in ataxia, very limited evidence exists for its use. We evaluated the efficacy of a home\u2010delivered, ataxia\u2010tailored biofeedback\u2010driven speech therapy in CAG\u2010SCA in 16 individuals with SCA1, 2, 3, or 6. Treatment was delivered intensively over 20\u2009days. Efficacy was evaluated by blinded ratings of intelligibility (primary) and acoustic measures (secondary) leveraging an intra\u2010individual control design. Intelligibility improved post\u2010treatment (Z\u2009=\u2009\u22123.18, <jats:italic>p<\/jats:italic>\u2009=\u20090.004) whilst remaining stable prior to treatment (Z\u2009=\u20090.53, <jats:italic>p<\/jats:italic>\u2009=\u20091.00).<\/jats:p>","DOI":"10.1002\/acn3.51613","type":"journal-article","created":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T11:36:50Z","timestamp":1655811410000},"page":"1310-1315","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Home\u2010based biofeedback speech treatment improves dysarthria in repeat\u2010expansion <scp>SCAs<\/scp>"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3505-2631","authenticated-orcid":false,"given":"Adam P.","family":"Vogel","sequence":"first","affiliation":[{"name":"Division of Translational Genomics of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research University of T\u00fcbingen, Germany &amp; Center for Neurology, University Hospital T\u00fcbingen  Germany"},{"name":"Centre for Neuroscience of Speech The University of Melbourne  Victoria Australia"},{"name":"Redenlab  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa H.","family":"Graf","sequence":"additional","affiliation":[{"name":"Division of Translational Genomics of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research University of T\u00fcbingen, Germany &amp; Center for Neurology, University Hospital T\u00fcbingen  Germany"},{"name":"Redenlab  Melbourne Australia"},{"name":"Therapiezentrum University Hospital T\u00fcbingen  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Magee","sequence":"additional","affiliation":[{"name":"Centre for Neuroscience of Speech The University of Melbourne  Victoria Australia"},{"name":"Redenlab  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludger","family":"Sch\u00f6ls","sequence":"additional","affiliation":[{"name":"Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research University of T\u00fcbingen, Germany &amp; Center for Neurology, University Hospital T\u00fcbingen  Germany"},{"name":"Center for Neurodegenerative Diseases (DZNE)  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Rommel","sequence":"additional","affiliation":[{"name":"Division of Translational Genomics of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research University of T\u00fcbingen, Germany &amp; Center for Neurology, University Hospital T\u00fcbingen  Germany"},{"name":"Therapiezentrum University Hospital T\u00fcbingen  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2280-7273","authenticated-orcid":false,"given":"Matthis","family":"Synofzik","sequence":"additional","affiliation":[{"name":"Division of Translational Genomics of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research University of T\u00fcbingen, Germany &amp; Center for Neurology, University Hospital T\u00fcbingen  Germany"},{"name":"Center for Neurodegenerative Diseases (DZNE)  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0074-3"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70183-6"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f7062"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008953.pub2"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-019-09258-4"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-020-01153-3"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1545968317712469"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23222"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000219042.60538.92"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-012-6547-x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-014-7511-8"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1044\/1058-0360(2006\/006)"},{"key":"e_1_2_9_14_1","first-page":"341","article-title":"PRAAT, a system for doing phonetics by computer","volume":"5","author":"Boersma P","year":"2001","journal-title":"Glot International"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2009.09.003"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/93.3.491"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-019-1013-9"}],"container-title":["Annals of Clinical and Translational Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.51613","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acn3.51613","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.51613","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T20:13:01Z","timestamp":1692735181000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/acn3.51613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,21]]},"references-count":16,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1002\/acn3.51613"],"URL":"https:\/\/doi.org\/10.1002\/acn3.51613","archive":["Portico"],"relation":{},"ISSN":["2328-9503","2328-9503"],"issn-type":[{"value":"2328-9503","type":"print"},{"value":"2328-9503","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,21]]},"assertion":[{"value":"2022-04-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}