{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T03:28:26Z","timestamp":1787801306258,"version":"build-2784847793"},"reference-count":49,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T00:00:00Z","timestamp":1656460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>To determine if the severity of olfactory dysfunction in isolated REM sleep behavior disorder (IRBD) predicts conversion to Parkinson's disease (PD) or dementia with Lewy bodies (DLB).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Olfaction was tested using the Japanese version of the University of Pennsylvania Smell Identification Test (UPSIT\u2010J) in 155 consecutive patients with polysomnography\u2010confirmed IRBD and 34 healthy controls. IRBD patients were followed up for 5.8\u2009\u00b1\u20093.2 (range 0.2\u201311) years. Thirty\u2010eight patients underwent repeat UPSIT\u2010J evaluation at 2.7\u2009\u00b1\u20091.3\u2009years after the baseline test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>UPSIT\u2010J score was lower in IRBD patients than in age\u2010 and sex\u2010matched controls. The receiver operating characteristic curve analysis showed that the optimal cutoff score of 22.5 in UPSIT\u2010J discriminated between IRBD patients and controls with a sensitivity of 94.3% and specificity of 81.8%. Anosmia (UPSIT\u2010J score\u2009&lt;\u200919) was present in 54.2% of IRBD patients. In total, 42 patients developed a neurodegenerative disease, of whom 17 had PD, 22 DLB, and 3 MSA. Kaplan\u2013Meier analysis showed that the short\u2010term risk of Lewy body disease (LBD) was higher in patients with anosmia than in those without anosmia. At baseline, the UPSIT\u2010J score was similar between patients who developed PD and DLB (p\u2009=\u20090.136). All three IRBD patients (100%) who developed MSA did not have anosmia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In IRBD patients, anosmia predicts a higher short\u2010term risk of transition to LBD but cannot distinguish between PD and DLB. At baseline, preserved odor identification may occur in latent MSA. Future IRBD neuroprotective trials should evaluate anosmia as a marker of prodromal LBD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.51615","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T13:23:45Z","timestamp":1656509025000},"page":"1177-1185","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Odor identification predicts the transition of patients with isolated\n                    <scp>RBD<\/scp>\n                    : A retrospective study"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6535-8260","authenticated-orcid":false,"given":"Tomoyuki","family":"Miyamoto","sequence":"first","affiliation":[{"name":"Department of Neurology Dokkyo Medical University Saitama Medical Center  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