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This study investigates the distribution patterns of hypometabolism in frontal lobe epilepsy (FLE) originating in different frontal regions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010four patients with FLE were grouped by EZ localization according to Brodmann areas (BAs): Group 1 (the frontal motor and premotor area), BAs 4, 6, and 8; Group 2 (the inferior frontal gyrus and opercular area), BAs 44, 45, and 47; Group 3 (the dorsal prefrontal area), BAs 9, 10, 11, and 46; and Group 4 (the medial frontal and anterior cingulate gyrus), BAs 32 and 24. Regions of extra\u2010EZ hypometabolism were statistically analyzed between FLE groups and healthy controls. Correlation analysis was performed to identify relationships between the intensity of hypometabolism and clinical characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant hypometabolism in the ipsilateral (Groups 1 and 4) or bilateral (Groups 2 and 3) anterior insulae was found. Groups 1 and 4 presented with limited distribution of extra\u2010EZ hypometabolism, whereas Groups 2 and 3 showed widely distributed extra\u2010EZ hypometabolism in the rectus gyrus, cingulate gyrus, and other regions. Additionally, the intensity of hypometabolism was correlated with epilepsy duration in Groups 2 and 3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>All FLE groups showed hypometabolism in the anterior insula. In addition, distinct patterns of extra\u2010EZ hypometabolism were identified for each FLE group. This quantitative FDG\u2010PET analysis expanded our understanding of the topography of epileptic networks and can guide EZ localization in the future.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.51630","type":"journal-article","created":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T04:54:47Z","timestamp":1657860887000},"page":"1336-1344","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Patterns of hypometabolism in frontal lobe epilepsy originating in different frontal regions"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0919-2606","authenticated-orcid":false,"given":"Zexian","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Neurology Zhejiang Hospital Hangzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology Second Affiliated Hospital, School of Medicine, Zhejiang University Hangzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0380-3912","authenticated-orcid":false,"given":"Shan","family":"Wang","sequence":"additional","affiliation":[{"name":"Epilepsy Center, Department of Neurology Second Affiliated Hospital, School of Medicine, Zhejiang University Hangzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cong","family":"Chen","sequence":"additional","affiliation":[{"name":"Epilepsy Center, Department of Neurology Second Affiliated Hospital, School of Medicine, Zhejiang University Hangzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenmin","family":"He","sequence":"additional","affiliation":[{"name":"Epilepsy Center, Department of Neurology Second Affiliated Hospital, School of Medicine, Zhejiang University Hangzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingli","family":"Hu","sequence":"additional","affiliation":[{"name":"Epilepsy Center, Department of Neurology Second Affiliated Hospital, School of Medicine, Zhejiang University Hangzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Second Affiliated Hospital, School of Medicine, Zhejiang University Hangzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junming","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Second Affiliated Hospital, School of Medicine, Zhejiang University Hangzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3145-7778","authenticated-orcid":false,"given":"Meiping","family":"Ding","sequence":"additional","affiliation":[{"name":"Epilepsy Center, Department of Neurology Second Affiliated Hospital, School of Medicine, Zhejiang University Hangzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Wang","sequence":"additional","affiliation":[{"name":"Epilepsy Center, Department of Neurology Second Affiliated Hospital, School of Medicine, Zhejiang University Hangzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0599-8872","authenticated-orcid":false,"given":"Yao","family":"Ding","sequence":"additional","affiliation":[{"name":"Epilepsy Center, Department of Neurology Second Affiliated Hospital, School of Medicine, Zhejiang University Hangzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,14]]},"reference":[{"issue":"4","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1684\/j.1950-6945.2004.tb00071.x","article-title":"Frontal lobe epilepsy","volume":"6","author":"Kellinghaus C","year":"2004","journal-title":"Epileptic Disord"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.10.1911"},{"key":"e_1_2_9_4_1","volume-title":"The epilepsies: seizures, syndromes and management","author":"Panayiotopoulos CP","year":"2005"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100032819"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-018-1130-9"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2011.03.004"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/10.3.206"},{"key":"e_1_2_9_9_1","first-page":"115","article-title":"The clinical signs and symptoms of frontal lobe seizures. 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