{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:02:24Z","timestamp":1791234144032,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T00:00:00Z","timestamp":1661558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["409865"],"award-info":[{"award-number":["409865"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["Vidi 917.113.349"],"award-info":[{"award-number":["Vidi 917.113.349"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Assess whether propranolol modulates the trigeminovascular system in both men and women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We investigated the effect of propranolol (80\u2009mg, 90\u2009min after oral administration, corresponding to <jats:italic>T<\/jats:italic><jats:sub>max<\/jats:sub>) on the increase in dermal blood flow of the forehead skin (innervated by the trigeminal nerve) by capsaicin application (0.6\u2009mg\/mL) and electrical stimulation (0.2\u20131.0\u2009mA) before and after placebo (grapefruit juice) or propranolol (oral solution diluted in grapefruit juice) in a randomized, double\u2010blind, placebo\u2010controlled cross\u2010over study, including healthy males (<jats:italic>n<\/jats:italic>\u2009=\u200910) and females on contraceptives (<jats:italic>n<\/jats:italic>\u2009=\u200911). Additionally, we compared our results with data from the Dutch IADB.nl prescription database by analyzing the change in triptan use after propranolol prescription in a population similar to our dermal blood flow study subjects (males and females, 20\u201339\u2009years old).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Dermal blood flow responses to capsaicin were significantly attenuated after propranolol, but not after placebo. When stratifying by sex, no significant changes in the capsaicin\u2010induced dermal blood flow were observed in females after propranolol, whereas they remained significant in males. Dermal blood flow responses to electrical stimulation were not modified in any case. In our prescription database study, after propranolol, a more pronounced decrease in triptan use was observed in male patients than in female patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Propranolol (80\u2009mg) inhibits capsaicin\u2010induced increases in dermal blood flow in a sex\u2010dependent manner. In patients, a more pronounced decrease in triptan use is observed in males when compared with females, suggesting an interaction between propranolol and sex steroids in the modulation of the trigeminovascular system.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.51640","type":"journal-article","created":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T10:05:13Z","timestamp":1661594713000},"page":"1405-1416","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Trigeminovascular effects of propranolol in men and women, role for sex steroids"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2912-3632","authenticated-orcid":false,"given":"Elo\u00edsa","family":"Rubio\u2010Beltr\u00e1n","sequence":"first","affiliation":[{"name":"Division of Pharmacology, Vascular Medicine and Metabolic Diseases, Department of Internal Medicine Erasmus University Medical Centre  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rianne M.","family":"Schoon","sequence":"additional","affiliation":[{"name":"Division of Pharmacology, Vascular Medicine and Metabolic Diseases, Department of Internal Medicine Erasmus University Medical Centre  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"van den Berg","sequence":"additional","affiliation":[{"name":"Division of Pharmacology, Vascular Medicine and Metabolic Diseases, Department of Internal Medicine Erasmus University Medical Centre  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catharina C. 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