{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:15:25Z","timestamp":1790820925985,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,9,3]],"date-time":"2022-09-03T00:00:00Z","timestamp":1662163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000890","name":"National Multiple Sclerosis Society","doi-asserted-by":"publisher","award":["RD4716A6\/3"],"award-info":[{"award-number":["RD4716A6\/3"]}],"id":[{"id":"10.13039\/100000890","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Recent studies suggested that the expansion of long\u2010standing multiple sclerosis (MS) lesions and an enlargement of choroid plexus may be linked to chronic inflammation and microglial activation. We investigated the potential association between plexus volume and subsequent lesion expansion in patients with relapsing\u2010remitting MS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Pre\u2010 and post\u2010gadolinium 3D\u2010T1, 3D FLAIR and diffusion tensor images were acquired from 49 patients. Choroid plexus (CP) volume (normalised by Total Intracranial Volume, TIV) and lesion activity were analysed between baseline and 48\u2009months. In addition, plexus volume was measured in 40 healthy controls of similar age and gender.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Baseline CP\/TIV ratio was significantly larger in RRMS patients compared to normal controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). CP\/TIV ratio remained stable in RRMS patients during follow\u2010up period. There was a strong correlation between baseline CP\/TIV ratio and subsequent rate of chronic lesion expansion (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), which was stronger in close proximity to CSF. A cut\u2010off of 98\u2009\u00d7\u200910\n                      <jats:sup>\u22125<\/jats:sup>\n                      CP\/TIV ratio predicted future lesion expansion with a sensitivity of 85% and specificity of 76%. CP\/TIV ratio larger than a cut\u2010off was associated with &gt;8\u2010fold increased risk of chronic lesion expansion. Baseline CP\/TIV ratio was also associated with change in Mean Diffusivity (MD) inside of chronic lesions. Furthermore\n                      <jats:italic>,<\/jats:italic>\n                      baseline CP\/TIV ratio significantly correlated with central brain atrophy. There was, however, no correlation between CP\/TIV ratio and volume of new lesions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Our data demonstrate that baseline CP\/TIV ratio predicts subsequent expansion of chronic periventricular MS lesions and associated tissue damage within and outside of chronic lesions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.51644","type":"journal-article","created":{"date-parts":[[2022,9,3]],"date-time":"2022-09-03T03:39:07Z","timestamp":1662176347000},"page":"1528-1537","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["Choroid plexus volume in multiple sclerosis predicts expansion of chronic lesions and brain atrophy"],"prefix":"10.1002","volume":"9","author":[{"given":"Samuel","family":"Klistorner","sequence":"first","affiliation":[{"name":"Save Sight Institute, Sydney Medical School University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H.","family":"Barnett","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre University of Sydney  Sydney New South Wales Australia"},{"name":"Sydney Neuroimaging Analysis Centre  Camperdown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Parratt","sequence":"additional","affiliation":[{"name":"Royal North Shore Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Con","family":"Yiannikas","sequence":"additional","affiliation":[{"name":"Royal North Shore Hospital  Sydney New South Wales 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