{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T15:44:12Z","timestamp":1766159052259,"version":"build-2065373602"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T00:00:00Z","timestamp":1666656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>HTT<\/jats:italic> full\u2010penetrance pathogenic repeat expansions, the genetic cause of Huntington's disease (HD), have been recently reported in a minority of frontotemporal dementia\/amyotrophic lateral sclerosis (ALS) patients (0.13%). We analyzed <jats:italic>HTT<\/jats:italic> CAG repeats in an Italian cohort of ALS patients (<jats:italic>n<\/jats:italic>\u2009=\u2009467) by repeat\u2010primed polymerase chain reaction. One patient harbored two expanded alleles in the <jats:italic>HTT<\/jats:italic> gene (42 and 37 CAG repeats). The absence of HD typical symptoms and the clinical picture consistent with ALS, corroborated by the diagnostic assessment, apparently excluded a misdiagnosis of HD.<\/jats:p>","DOI":"10.1002\/acn3.51673","type":"journal-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T06:10:53Z","timestamp":1666764653000},"page":"1820-1825","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Analysis of <scp><i>HTT<\/i> CAG<\/scp> repeat expansion in Italian patients with amyotrophic lateral sclerosis"],"prefix":"10.1002","volume":"9","author":[{"given":"Arianna","family":"Manini","sequence":"first","affiliation":[{"name":"Dino Ferrari Center, Department of Pathophysiology and Transplantation University of Milan  Milan 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