{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T01:42:44Z","timestamp":1778809364573,"version":"3.51.4"},"reference-count":49,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T00:00:00Z","timestamp":1667606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005089","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["Z210009"],"award-info":[{"award-number":["Z210009"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013090","name":"Science and Technology Innovation Project of Longhua Hospital","doi-asserted-by":"publisher","award":["2021ZD0201605"],"award-info":[{"award-number":["2021ZD0201605"]}],"id":[{"id":"10.13039\/501100013090","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We investigated both the metabolic differences and interictal\/ictal discharges of the anterior nucleus of the thalamus (ANT) in patients with epilepsy to clarify the relationship between the ANT and the epileptic network.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nineteen patients with drug\u2010resistant epilepsy who underwent stereoelectroencephalography were studied. Metabolic differences in ANT were analyzed using [18F] fluorodeoxyglucose\u2013positron emission tomography with three\u2010dimensional (3D) visual and quantitative analyses. Interictal and ictal discharges in the ANT were analyzed using visual and time\u2010frequency analyses. The relationship between interictal discharge and metabolic differences was analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that patients with temporal lobe epilepsy (TLE) showed significant metabolic differences in bilateral ANT compared with extratemporal lobe epilepsy in 3D visual and quantitative analyses. Four types of interictal activities were recorded from the ANT: spike, high\u2010frequency oscillation (HFO), slow\u2010wave, and \u03b1\u2010rhythmic activity. Spike and HFO waveforms were recorded mainly in patients with TLE. Two spike patterns were recorded: synchronous and independent. In 83.3% of patients, ANT was involved during seizures. Three seizure onset types of ANT were recorded: low\u2010voltage fast activity, rhythmic spikes, and theta band discharge. The time interval of seizure onset between the seizure onset zone and ANT showed two patterns: immediate and delayed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>ANT can receive either interictal discharges or ictal discharges which propagate from the epileptogenic zones. Independent epileptic discharges can also be recorded from the ANT in some patients. Metabolic anomalies and epileptic discharges in the ANT indicate that the ANT plays a role in the epileptic network in most patients with epilepsy, especially TLE.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.51693","type":"journal-article","created":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T17:59:45Z","timestamp":1667671185000},"page":"2010-2024","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The anterior nucleus of the thalamus plays a role in the epileptic network"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7765-7404","authenticated-orcid":false,"given":"Hao","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Functional Neurosurgery Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2463-748X","authenticated-orcid":false,"given":"Xueyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Functional Neurosurgery Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6885-7105","authenticated-orcid":false,"given":"Tao","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Functional Neurosurgery Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duanyu","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Functional Neurosurgery Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Functional Neurosurgery Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Functional Neurosurgery Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuiping","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Functional Neurosurgery Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Shu","sequence":"additional","affiliation":[{"name":"Department of Functional Neurosurgery Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Comprehensive Epilepsy Center of Beijing, Beijing Key Laboratory of Neuromodulation Xuanwu Hospital, Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5147-3068","authenticated-orcid":false,"given":"Liankun","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Neurology, Comprehensive Epilepsy Center of Beijing, Beijing Key Laboratory of Neuromodulation Xuanwu Hospital, Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(03)00664-1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2014.59"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24376"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1011-17.2017"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004035"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000011003"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1937.02260220069003"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02536.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001334"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2015.08.001"},{"key":"e_1_2_8_12_1","volume-title":"Epileptic Seizures; 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