{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T15:16:54Z","timestamp":1790090214065,"version":"4.0.1"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T00:00:00Z","timestamp":1668816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100002243","name":"National Ataxia Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01 NS104423"],"award-info":[{"award-number":["R01 NS104423"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01 NS118179"],"award-info":[{"award-number":["R01 NS118179"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01 NS124854"],"award-info":[{"award-number":["R01 NS124854"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The cerebellum has been identified as the key brain region that modulates reward processing in animal models. Consistently, we recently found that people with cerebellar ataxia have impulsive and compulsive behaviors (ICBs), the main symptoms related to abnormal reward processing. Due to the lack of a validated scale to quantitatively measure ICBs in cerebellar disorders, we aim to develop and validate a new scale, Cerebellar Impulsivity\u2013Compulsivity Assessment (CIA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited 62 cerebellar ataxia cases, categorized into those with ICBs and those without. We developed a preliminary version of CIA, containing 17 questions. We studied the internal consistency, test\u2013retest reliability, and inter\u2010rater reliability to formulate the final version of CIA, which constitutes only 10 questions. The receiver operating characteristic curve (ROC) was generated to assess the sensitivity and specificity of CIA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cerebellar ataxia cases with ICBs have threefold higher total preliminary CIA scores than those without ICBs (12.06\u2009\u00b1\u20095.96 <jats:italic>vs.<\/jats:italic> 4.68\u2009\u00b1\u20093.50, <jats:italic>p\u00a0=\u00a00.038<\/jats:italic>). Cronbach's alpha revealed good internal consistency across all items (<jats:italic>\u03b1\u2009&gt;\u20090.70<\/jats:italic>). By performing the test\u2013retest reliability and inter\u2010rater reliability on the preliminary version of CIA, we excluded seven questions (<jats:italic>r\u2009&lt;\u20090.70)<\/jats:italic> and generated the final version of CIA. Based on the ROC, a score of 8.0 in CIA was chosen as the cut\u2010off for ICBs in individuals with cerebellar ataxia with 81% sensitivity and 81% specificity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>CIA is a novel tool to assess ICBs in cerebellar ataxia and broaden our understanding of the cerebellum\u2010related cognitive and behavioral symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.51698","type":"journal-article","created":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T14:40:35Z","timestamp":1668868835000},"page":"48-57","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cerebellar impulsivity\u2013compulsivity assessment scale"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9607-974X","authenticated-orcid":false,"given":"Chi\u2010Ying R.","family":"Lin","sequence":"first","affiliation":[{"name":"Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology Baylor College of Medicine  Houston Texas USA"},{"name":"Alzheimer's Disease and Memory Disorders Center, Department of Neurology Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5460-0234","authenticated-orcid":false,"given":"Nadia","family":"Amokrane","sequence":"additional","affiliation":[{"name":"Department of Neurology Columbia University Medical Center  New York New York USA"},{"name":"Initiative of Columbia Ataxia and Tremor Columbia University Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology Columbia University Medical Center  New York New York USA"},{"name":"Initiative of Columbia Ataxia and Tremor Columbia University Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5443-0610","authenticated-orcid":false,"given":"Tiffany X.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology Columbia University Medical Center  New York New York USA"},{"name":"Initiative of Columbia Ataxia and Tremor Columbia University Medical Center  New York New York USA"},{"name":"Department of Biomedical Engineering Whiting School of Engineering, Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruo\u2010Yah","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Neurology Columbia University Medical Center  New York New York USA"},{"name":"Initiative of Columbia Ataxia and Tremor Columbia University Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Trinh","sequence":"additional","affiliation":[{"name":"Department of Neurology Columbia University Medical Center  New York New York USA"},{"name":"Initiative of Columbia Ataxia and Tremor Columbia University Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Minyetty","sequence":"additional","affiliation":[{"name":"Department of Neurology Columbia University Medical Center  New York New York USA"},{"name":"Initiative of Columbia Ataxia and Tremor Columbia University Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haidyn","family":"Emmerich","sequence":"additional","affiliation":[{"name":"Department of Neurology Columbia University Medical Center  New York New York USA"},{"name":"Initiative of Columbia Ataxia and Tremor Columbia University Medical Center  New York New York 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