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We investigated the progression of gait deficits via mobile digital measurements in conjunction with clinical and patient\u2010reported outcome parameters. Our cohort included adult HSP patients (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a055) with up to 77\u00a0months of follow\u2010up. Gait speed showed a significant association with SPRS progression. Changes in stride time and gait variability correlated to fear of falling and quality of life, providing evidence that gait parameters are meaningful measures of HSP progression.\n                  <\/jats:p>","DOI":"10.1002\/acn3.51725","type":"journal-article","created":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T11:46:52Z","timestamp":1673264812000},"page":"447-452","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Mobile digital gait analysis objectively measures progression in hereditary spastic paraplegia"],"prefix":"10.1002","volume":"10","author":[{"given":"Evelyn","family":"Loris","sequence":"first","affiliation":[{"name":"Department of Molecular Neurology Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU)  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malte","family":"Ollenschl\u00e4ger","sequence":"additional","affiliation":[{"name":"Department of Molecular Neurology Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU)  Erlangen Germany"},{"name":"Machine Learning and Data Analytics Lab, Department Artificial Intelligence in Biomedical Engineering Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU)  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Greinwalder","sequence":"additional","affiliation":[{"name":"Department of Molecular Neurology Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU)  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Eskofier","sequence":"additional","affiliation":[{"name":"Machine Learning and Data Analytics Lab, Department Artificial Intelligence in Biomedical Engineering Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU)  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Winkler","sequence":"additional","affiliation":[{"name":"Department of Molecular Neurology Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU)  Erlangen Germany"},{"name":"Center for Rare Diseases Erlangen (ZSEER) Universit\u00e4tsklinikum Erlangen  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiko","family":"Ga\u00dfner","sequence":"additional","affiliation":[{"name":"Department of Molecular Neurology Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU)  Erlangen Germany"},{"name":"Fraunhofer IIS Fraunhofer Institute for Integrated Circuits IIS  91058 Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2172-7386","authenticated-orcid":false,"given":"Martin","family":"Regensburger","sequence":"additional","affiliation":[{"name":"Department of Molecular Neurology Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU)  Erlangen Germany"},{"name":"Center for Rare Diseases Erlangen (ZSEER) Universit\u00e4tsklinikum Erlangen  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30235-2"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000228242.53336.90"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2011.03443.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2010.61"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/09638288.2019.1610084"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-020-1338-4"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3233\/NRE-141196"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1590\/0004-282x20180013"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28523"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-019-09573-w"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2010.07.009"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2011.01.009"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0164623"},{"key":"e_1_2_8_15_1","doi-asserted-by":"crossref","unstructured":"MartindaleCF RothN GasnerH et\u00a0al.Mobile gait analysis using personalised hidden Markov models for hereditary spastic paraplegia patients. 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