{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T13:58:30Z","timestamp":1747144710446,"version":"3.40.5"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T00:00:00Z","timestamp":1674518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Opioids effectively reduce chronic pain, but present significant side effects including opioid\u2010induced constipation. Oxycodone\/naloxone decreases pain and constipation in cancer patients, however its effect on spinal cord injury population remains understudied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We assessed whether oxycodone\/naloxone reduces pain, constipation, and severity of autonomic dysreflexia in an individual with spinal cord injury. A 55\u2010year\u2010old male with C5 lesion presented with chief complaint of chronic pain received 5\/2.5\u00a0mg and 20\/10\u2009mg oxycodone\/naloxone for 6 and 2\u2009weeks, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Oxycodone\/naloxone improved pain, bowel function, and autonomic dysreflexia severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Oxycodone\/naloxone was effective in managing chronic pain and constipation in the studied case.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.51734","type":"journal-article","created":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T13:21:02Z","timestamp":1674566462000},"page":"453-458","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["No pain, no strain: Targin\u00ae mitigates pain and constipation following spinal cord injury"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7972-9344","authenticated-orcid":false,"given":"Rahul","family":"Sachdeva","sequence":"first","affiliation":[{"name":"International Collaboration on Repair Discoveries University of British Columbia British Columbia Vancouver Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Hosseinzadeh","sequence":"additional","affiliation":[{"name":"International Collaboration on Repair Discoveries University of British Columbia British Columbia Vancouver Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"Rizzardo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Community Internal Medicine University of British Columbia British Columbia Vancouver Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Maharaj","sequence":"additional","affiliation":[{"name":"International Collaboration on Repair Discoveries University of British Columbia British Columbia Vancouver Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Berger","sequence":"additional","affiliation":[{"name":"International Collaboration on Repair Discoveries University of British Columbia British Columbia Vancouver Canada"},{"name":"Department of Medicine, Division of Physical Medicine and Rehabilitation University of British Columbia British Columbia Vancouver Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0022-7972","authenticated-orcid":false,"given":"Andrei","family":"Krassioukov","sequence":"additional","affiliation":[{"name":"International Collaboration on Repair Discoveries University of British Columbia British Columbia Vancouver Canada"},{"name":"Department of Medicine, Division of Physical Medicine and Rehabilitation University of British Columbia British Columbia Vancouver Canada"},{"name":"Spinal Cord Program, GF Strong Rehabilitation Centre University of British Columbia British Columbia Vancouver Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,1,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2012.10.035"},{"key":"e_1_2_7_3_1","article-title":"Management of pain in individuals with spinal cord injury: guideline of the German\u2010speaking medical society for spinal cord injury","volume":"17","author":"Franz S","year":"2019","journal-title":"Ger Med Sci"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1545968315624777"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2011.156"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2008.136"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.4055\/cios.2018.10.1.33"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajco.13561"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10081673"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41393-021-00744-z"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2013.03.008"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-015-0303-0"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2017.5343"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2017.05.002"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/practneurol-2021-002956"},{"volume-title":"Autonomic dysreflexia","year":"2022","author":"Allen KJ","key":"e_1_2_7_16_1"},{"volume-title":"Oral","year":"2020","author":"Purdue Pharma","key":"e_1_2_7_17_1"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2008.06.012"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-014-2435-5"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S84711"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1179\/204577211X13207446293695"},{"issue":"3","key":"e_1_2_7_22_1","article-title":"Validation of digital visual analog scale pain scoring with a traditional paper\u2010based visual analog scale in adults","volume":"2","author":"Delgado DA","year":"2018","journal-title":"J Am Acad Orthop Surg Glob Res Rev"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.02.007"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.sc.3101887"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14349"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520510012208"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1497.2001.016009606.x"},{"key":"e_1_2_7_28_1","unstructured":"NasreddineZ.Montreal Cognitive Assessment (MoCA) Administration and Scoring Instructions.2004[cited 2022];https:\/\/www.parkinsons.va.gov\/resources\/MoCA\u2010Instructions\u2010English.pdf"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2013.3148"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20102464"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12646"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-014-0177-9"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2009.03.012"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.2174\/13894501113149990210"}],"container-title":["Annals of Clinical and Translational Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.51734","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acn3.51734","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.51734","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T03:13:40Z","timestamp":1692587620000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/acn3.51734"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,24]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1002\/acn3.51734"],"URL":"https:\/\/doi.org\/10.1002\/acn3.51734","archive":["Portico"],"relation":{},"ISSN":["2328-9503","2328-9503"],"issn-type":[{"type":"print","value":"2328-9503"},{"type":"electronic","value":"2328-9503"}],"subject":[],"published":{"date-parts":[[2023,1,24]]},"assertion":[{"value":"2022-11-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}