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Here, we review the pathophysiology of essential tremor and Parkinson's disease, the two most common movement disorders, with a focus on mechanisms underlying the genesis of abnormal firing patterns in the implicated neural circuits. Aberrant burst firing of neurons in the cerebello\u2010thalamo\u2010cortical and basal ganglia\u2010thalamo\u2010cortical circuits contribute to the clinical symptoms of essential tremor and Parkinson's disease, respectively, and T\u2010type calcium channels play a key role in regulating this activity in both the disorders. Accordingly, modulating T\u2010type calcium channel activity has received attention as a potentially promising therapeutic approach to normalize abnormal burst firing in these diseases. In this review, we explore the evidence supporting the theory that T\u2010type calcium channel blockers can ameliorate the pathophysiologic mechanisms underlying essential tremor and Parkinson's disease, furthering the case for clinical investigation of these compounds. We conclude with key considerations for future investigational efforts, providing a critical framework for the development of much needed agents capable of targeting the dysfunctional circuitry underlying movement disorders such as essential tremor, Parkinson's disease, and beyond.<\/jats:p>","DOI":"10.1002\/acn3.51735","type":"journal-article","created":{"date-parts":[[2023,2,4]],"date-time":"2023-02-04T10:58:36Z","timestamp":1675508316000},"page":"462-483","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["T\u2010type calcium channels as therapeutic targets in essential tremor and Parkinson's disease"],"prefix":"10.1002","volume":"10","author":[{"given":"Lillian G.","family":"Matthews","sequence":"first","affiliation":[{"name":"Praxis Precision Medicines  Boston Massachusetts 02110 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corey 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