{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T03:22:45Z","timestamp":1789788165996,"version":"4.0.1"},"reference-count":61,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T00:00:00Z","timestamp":1675814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["1K2 RX002947"],"award-info":[{"award-number":["1K2 RX002947"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Rapid eye movement (REM) sleep behavior disorder (RBD) is widely considered a prodromal synucleinopathy, as most with RBD develop overt synucleinopathy within ~10\u2009years. Accordingly, RBD offers an opportunity to test potential treatments at the earliest stages of synucleinopathy. The North American Prodromal Synucleinopathy (NAPS) Consortium has created a multisite RBD participant, primarily clinic\u2010based cohort to better understand characteristics at diagnosis, and in future work, identify predictors of phenoconversion, develop synucleinopathy biomarkers, and enable early stage clinical trial enrollment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants \u226518\u2009years of age with overnight polysomnogram\u2010confirmed RBD without Parkinson's disease, dementia, multiple system atrophy, or narcolepsy were enrolled from nine sites across North America (8\/2018 to 4\/2021). Data collection included family\/personal history of RBD and standardized assessments of cognitive, motor, sensory, and autonomic function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Outcomes are primarily reported based on sex (361 total:\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0295 male,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a066 female), and secondarily based on history of antidepressant use (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0200 with,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0154 without; with correction for sex differences) and based on extent of synucleinopathy burden (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a056 defined as isolated RBD,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0305 defined as RBD+ [i.e., exhibiting \u22651 abnormality]). Overall, these participants commonly demonstrated abnormalities in global cognition (MoCA; 38%), motor function (alternate tap test; 48%), sensory (BSIT; 57%), autonomic function (orthostatic hypotension, 38.8%), and anxiety\/depression (BAI and PHQ\u20109; 39.3% and 31%, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>These RBD participants, assessed with extensive history, demographic, cognitive, motor, sensory, and autonomic function demonstrated a lack of sex differences and high frequency of concomitant neurological abnormalities. These participants will be valuable for future longitudinal study and neuroprotective clinical trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.51738","type":"journal-article","created":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T03:19:32Z","timestamp":1675826372000},"page":"520-535","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Baseline characteristics of the North American prodromal Synucleinopathy cohort"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6992-6851","authenticated-orcid":false,"given":"Jonathan E.","family":"Elliott","sequence":"first","affiliation":[{"name":"VA Portland Health Care System Research Service  Portland Oregon USA"},{"name":"Oregon Health &amp; Science University  Neurology, Portland Oregon 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