{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:55:02Z","timestamp":1792014902080,"version":"4.4.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T00:00:00Z","timestamp":1677542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007458","name":"Qatar Foundation","doi-asserted-by":"publisher","award":["NPRP12S\u20100213\u2010190080"],"award-info":[{"award-number":["NPRP12S\u20100213\u2010190080"]}],"id":[{"id":"10.13039\/100007458","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study compared the utility of corneal nerve measures with brain volumetry for predicting progression to dementia in individuals with mild cognitive impairment (MCI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants with no cognitive impairment (NCI) and MCI underwent assessment of cognitive function, brain volumetry of thirteen brain structures, including the hippocampus and corneal confocal microscopy (CCM). Participants with MCI were followed up in the clinic to identify progression to dementia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 107 participants with MCI aged 68.4\u2009\u00b1\u20097.7\u2009years, 33 (30.8%) progressed to dementia over 2.6\u2010years of\u00a0follow\u2010up. Compared to participants with NCI (<jats:italic>n<\/jats:italic>\u00a0=\u00a012), participants who remained with MCI (<jats:italic>n<\/jats:italic>\u00a0=\u00a074) or progressed to dementia had lower corneal\u00a0nerve measures (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Progressors had lower corneal\u00a0nerve measures, hippocampal, and whole brain volume (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001).\u00a0However, CCM had a higher prognostic accuracy (72%\u201375% vs 68%\u201369%) for identifying individuals who progressed to dementia compared to hippocampus and whole brain volume. The adjusted odds ratio for progression to dementia was 6.1 (95% CI: 1.6\u201323.8) and 4.1 (95% CI: 1.2\u201314.2) higher with abnormal CCM measures, but was not significant for abnormal brain volume.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Abnormal CCM measures have a higher prognostic accuracy than brain volumetry for predicting progression from MCI to dementia.\u00a0Further work is\u00a0required\u00a0to validate the predictive ability of CCM compared to other established biomarkers of dementia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.51747","type":"journal-article","created":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T10:34:38Z","timestamp":1677580478000},"page":"599-609","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Corneal nerve loss predicts dementia in patients with mild cognitive impairment"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6936-1248","authenticated-orcid":false,"given":"Georgios","family":"Ponirakis","sequence":"first","affiliation":[{"name":"Department of Medicine Weill Cornell Medicine\u2010Qatar, Qatar Foundation  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanadi","family":"Al Hamad","sequence":"additional","affiliation":[{"name":"Geriatric &amp; Memory Clinic Rumailah Hospital, Hamad Medical Corporation  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dunya A. 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