{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:26:28Z","timestamp":1789500388301,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T00:00:00Z","timestamp":1679011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7194323"],"award-info":[{"award-number":["7194323"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The co\u2010morbidity of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP)\/autoimmune nodopathies with nephropathy has been gradually known in recent years. This study was intended to explore the clinical, serological and neuropathological features of seven patients with CIDP\/autoimmune nodopathies and nephropathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Among 83 CIDP patients, seven were identified with nephropathy. Their clinical, electrophysiological and laboratory examination data were collected. The nodal\/paranodal antibodies were tested. The sural biopsies were performed in all the patients, and renal biopsies were operated in 6 patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Six patients had chronic onsets and one had an acute onset. Four patients exhibited peripheral neuropathy preceding nephropathy while two showed concurrent onset of neuropathy and nephropathy, and one started with nephropathy. All the patients showed demyelination in electrophysiological examination. Nerve biopsies showed mild to moderate mixed neuropathies including demyelinating and axonal changes in all patients. Renal biopsies showed membranous nephropathy in all 6 patients. Immunotherapy was effective in all patients, with two patients showing good response to corticosteroid treatment alone. Four of the patients were positive to anti\u2010CNTN1 antibody. Compared with anti\u2010CNTN1 antibody\u2010negative patients, antibody\u2010positive patients had a higher proportion of ataxia (3\/4 vs. 1\/3), autonomic dysfunction (3\/4 vs. 1\/3), less frequent antecedent infections (1\/4 vs. 2\/3), higher cerebrospinal fluid proteins (3.2\u00a0g\/L vs. 1.69\u2009g\/L), more frequent conduction block on electrophysiological examination (3\/4 vs. 1\/3), higher myelinated nerve fiber density, and positive CNTN1 expression in the glomeruli of kidney tissues.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Anti\u2010CNTN1 antibody was the most frequent antibody in this group of patients with CIDP\/autoimmune nodopathies and nephropathy. Our study suggested that there might be some clinical and pathological differences between the antibody positive and negative patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.51754","type":"journal-article","created":{"date-parts":[[2023,3,18]],"date-time":"2023-03-18T01:43:10Z","timestamp":1679103790000},"page":"706-718","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["<scp>CIDP<\/scp>\n                    \/autoimmune nodopathies with nephropathy: a case series study"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5471-8523","authenticated-orcid":false,"given":"Yuwei","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Neurology Peking University First Hospital  8 Xishiku Street, Xicheng District Beijing 100034 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