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Of three ICI\u2010MG patients with AChR autoantibodies, only one showed complement activation and modulation\/blocking potency, resembling idiopathic MG. In contrast, AChR autoantibody\u2010mediated effector functions were not detected in the other two patients, questioning the role of their AChR autoantibodies as key mediators of pathology. The contrasting properties of AChR autoantibodies in these cases challenge the accuracy of serological testing in establishing definite ICI\u2010MG diagnoses and underscore the importance of a thorough clinical assessment when evaluating ICI\u2010related adverse events.<\/jats:p>","DOI":"10.1002\/acn3.51761","type":"journal-article","created":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T11:18:35Z","timestamp":1678965515000},"page":"825-831","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Clinicoserological insights into patients with immune checkpoint inhibitor\u2010induced myasthenia gravis"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4754-2141","authenticated-orcid":false,"given":"Gianvito","family":"Masi","sequence":"first","affiliation":[{"name":"Department of Immunobiology Yale School of Medicine  New Haven Connecticut 06511 USA"},{"name":"Department of 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