{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:17:17Z","timestamp":1791209837120,"version":"4.1.0"},"reference-count":164,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T00:00:00Z","timestamp":1680739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>LRRK2<\/jats:italic> variants are implicated in both familial and sporadic PD. <jats:italic>LRRK2\u2010<\/jats:italic>PD has a generally benign clinical presentation and variable pathology, with inconsistent presence of Lewy bodies and marked Alzheimer's disease pathology. The mechanisms underlying <jats:italic>LRRK2\u2010<\/jats:italic>PD are still unclear, but inflammation, vesicle trafficking, lysosomal homeostasis, and ciliogenesis have been suggested, among others. As novel therapies targeting LRRK2 are under development, understanding the role and function of LRRK2 in PD is becoming increasingly important. Here, we outline the epidemiological, pathophysiological, and clinical features of <jats:italic>LRRK2<\/jats:italic>\u2010PD, and discuss the arising therapeutic approaches targeting LRRK2 and possible future directions for research.<\/jats:p>","DOI":"10.1002\/acn3.51776","type":"journal-article","created":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T09:24:44Z","timestamp":1680773084000},"page":"850-864","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":106,"title":["<scp>LRRK2<\/scp> and Parkinson's disease: from genetics to targeted therapy"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9385-3920","authenticated-orcid":false,"given":"Yuri L.","family":"Sosero","sequence":"first","affiliation":[{"name":"Montreal Neurological Institute McGill University  Montr\u00e9al Qu\u00e9bec H3A 1A1 Canada"},{"name":"Department of Human Genetics McGill University  Montr\u00e9al Qu\u00e9bec H3A 1A1 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0332-234X","authenticated-orcid":false,"given":"Ziv","family":"Gan\u2010Or","sequence":"additional","affiliation":[{"name":"Montreal Neurological Institute McGill University  Montr\u00e9al Qu\u00e9bec H3A 1A1 Canada"},{"name":"Department of Human Genetics McGill University  Montr\u00e9al Qu\u00e9bec H3A 1A1 Canada"},{"name":"Department of Neurology and Neurosurgery McGill University  Montr\u00e9al Qu\u00e9bec H3A 0G4 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,6]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-181474"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-020-00218-x"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2020.104782"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70175-2"},{"issue":"10","key":"e_1_2_15_6_1","first-page":"627","article-title":"A big family of paralysis agitans (author's transl)","volume":"18","author":"Nukada H","year":"1978","journal-title":"Rinsho Shinkeigaku"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10113"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.10.023"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.11.005"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70117-0"},{"issue":"9457","key":"e_1_2_15_11_1","first-page":"415","article-title":"A common LRRK2 mutation in idiopathic Parkinson's disease","volume":"365","author":"Gilks WP","year":"2005","journal-title":"Lancet"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2005.04.103"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.604"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.21225"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25600"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M708718200"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.025437"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2014.00032"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2020.01.001"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2935"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32452"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3004485"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2019.00013"},{"key":"e_1_2_15_24_1","first-page":"8093124","article-title":"Genetic analysis of LRRK2 R1628P in Parkinson's disease in Asian populations","volume":"2017","author":"Zhang Y","year":"2017","journal-title":"Parkinsons Dis"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2006.12.001"},{"key":"e_1_2_15_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2021.02.018"},{"key":"e_1_2_15_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aai7635"},{"key":"e_1_2_15_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-08912-9"},{"key":"e_1_2_15_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27845"},{"key":"e_1_2_15_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.01.025"},{"key":"e_1_2_15_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26094"},{"key":"e_1_2_15_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)30203-4"},{"key":"e_1_2_15_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ensci.2015.08.001"},{"key":"e_1_2_15_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.11.033"},{"key":"e_1_2_15_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27295"},{"key":"e_1_2_15_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2020.07.002"},{"key":"e_1_2_15_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30320-5"},{"key":"e_1_2_15_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27974"},{"key":"e_1_2_15_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00218-X"},{"key":"e_1_2_15_40_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.2704"},{"key":"e_1_2_15_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-019-0836-x"},{"key":"e_1_2_15_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.04.011"},{"key":"e_1_2_15_43_1","doi-asserted-by":"publisher","DOI":"10.1159\/000289232"},{"key":"e_1_2_15_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2014.09.033"},{"key":"e_1_2_15_45_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318227042d"},{"key":"e_1_2_15_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.irn.2017.01.009"},{"key":"e_1_2_15_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2013.05.008"},{"key":"e_1_2_15_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12489"},{"key":"e_1_2_15_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23773"},{"key":"e_1_2_15_50_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0108982"},{"key":"e_1_2_15_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2020.104996"},{"key":"e_1_2_15_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-019-0301-2"},{"key":"e_1_2_15_53_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002304"},{"key":"e_1_2_15_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh667"},{"key":"e_1_2_15_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2006.04.001"},{"key":"e_1_2_15_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26614"},{"key":"e_1_2_15_57_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.185231"},{"key":"e_1_2_15_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25647"},{"key":"e_1_2_15_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2015.05.002"},{"key":"e_1_2_15_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-49969-7_2"},{"key":"e_1_2_15_61_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00283"},{"key":"e_1_2_15_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27527"},{"key":"e_1_2_15_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-011-0653-2"},{"key":"e_1_2_15_64_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2019-322338"},{"key":"e_1_2_15_65_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X16666180222165418"},{"key":"e_1_2_15_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18755-4"},{"key":"e_1_2_15_67_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11050861"},{"key":"e_1_2_15_68_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abp8869"},{"key":"e_1_2_15_69_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST20180463"},{"key":"e_1_2_15_70_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00193"},{"key":"e_1_2_15_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-017-0010-8"},{"issue":"2","key":"e_1_2_15_72_1","first-page":"408","article-title":"Inflammatory bowel disease and Parkinson's disease: common pathophysiological links","volume":"70","author":"Lee HS","year":"2021","journal-title":"Gut"},{"key":"e_1_2_15_73_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aai7795"},{"key":"e_1_2_15_74_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004412"},{"key":"e_1_2_15_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-023-00457-5"},{"key":"e_1_2_15_76_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9122565"},{"key":"e_1_2_15_77_1","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20180248"},{"key":"e_1_2_15_78_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201798099"},{"key":"e_1_2_15_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2011.06.008"},{"key":"e_1_2_15_80_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1812196115"},{"key":"e_1_2_15_81_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv314"},{"key":"e_1_2_15_82_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.164152"},{"key":"e_1_2_15_83_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2019.1603545"},{"key":"e_1_2_15_84_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1717590115"},{"key":"e_1_2_15_85_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-202138"},{"key":"e_1_2_15_86_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-161020"},{"key":"e_1_2_15_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1469-5"},{"key":"e_1_2_15_88_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-021-00265-y"},{"key":"e_1_2_15_89_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2015.1067364"},{"key":"e_1_2_15_90_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-022-00281-6"},{"key":"e_1_2_15_91_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-016-0140-1"},{"key":"e_1_2_15_92_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-49969-7_5"},{"key":"e_1_2_15_93_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.13305"},{"key":"e_1_2_15_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3350"},{"key":"e_1_2_15_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2008.05217.x"},{"key":"e_1_2_15_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2021.02.061"},{"key":"e_1_2_15_97_1","doi-asserted-by":"publisher","DOI":"10.1042\/EBC20210016"},{"key":"e_1_2_15_98_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2019.1603548"},{"key":"e_1_2_15_99_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.40202"},{"key":"e_1_2_15_100_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddz201"},{"key":"e_1_2_15_101_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e12-08-0598"},{"key":"e_1_2_15_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.05.018"},{"key":"e_1_2_15_103_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddx320"},{"key":"e_1_2_15_104_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3791-16.2017"},{"key":"e_1_2_15_105_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202012095"},{"key":"e_1_2_15_106_1","doi-asserted-by":"publisher","DOI":"10.3109\/08830185.2014.936587"},{"key":"e_1_2_15_107_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001315"},{"key":"e_1_2_15_108_1","doi-asserted-by":"publisher","DOI":"10.3109\/10409239009090616"},{"key":"e_1_2_15_109_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23614"},{"key":"e_1_2_15_110_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv179"},{"key":"e_1_2_15_111_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25629"},{"key":"e_1_2_15_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13413-w"},{"key":"e_1_2_15_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-022-00354-3"},{"key":"e_1_2_15_114_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28815"},{"key":"e_1_2_15_115_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24781"},{"key":"e_1_2_15_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2016.08.059"},{"key":"e_1_2_15_117_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24777"},{"key":"e_1_2_15_118_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-018-0860-4"},{"key":"e_1_2_15_119_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28066"},{"key":"e_1_2_15_120_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.5845"},{"key":"e_1_2_15_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2018.12.014"},{"key":"e_1_2_15_122_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27193"},{"key":"e_1_2_15_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2016.07.015"},{"key":"e_1_2_15_124_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004058"},{"key":"e_1_2_15_125_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abj2658"},{"key":"e_1_2_15_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2021.108822"},{"key":"e_1_2_15_127_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318198db11"},{"key":"e_1_2_15_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2017.08.002"},{"key":"e_1_2_15_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2018.11.021"},{"key":"e_1_2_15_130_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.1016040"},{"key":"e_1_2_15_131_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr348"},{"key":"e_1_2_15_132_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaa3634"},{"key":"e_1_2_15_133_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0893-5"},{"key":"e_1_2_15_134_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201798694"},{"key":"e_1_2_15_135_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aas9292"},{"key":"e_1_2_15_136_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20170014"},{"key":"e_1_2_15_137_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27818"},{"key":"e_1_2_15_138_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-181505"},{"key":"e_1_2_15_139_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aar5429"},{"key":"e_1_2_15_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2008.02.010"},{"key":"e_1_2_15_141_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr.08.2008.0632"},{"key":"e_1_2_15_142_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-010-0669-y"},{"key":"e_1_2_15_143_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000240220.33950.0c"},{"key":"e_1_2_15_144_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20731"},{"key":"e_1_2_15_145_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20791"},{"key":"e_1_2_15_146_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000326575.20829.45"},{"key":"e_1_2_15_147_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-011-9696-y"},{"key":"e_1_2_15_148_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27225"},{"key":"e_1_2_15_149_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000125015.06989.DB"},{"key":"e_1_2_15_150_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21281"},{"key":"e_1_2_15_151_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22096"},{"key":"e_1_2_15_152_1","doi-asserted-by":"publisher","DOI":"10.1159\/000113460"},{"key":"e_1_2_15_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2008.07.010"},{"key":"e_1_2_15_154_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22677"},{"key":"e_1_2_15_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2011.11.019"},{"key":"e_1_2_15_156_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-018-0617-y"},{"key":"e_1_2_15_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2018.11.007"},{"key":"e_1_2_15_158_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20814"},{"key":"e_1_2_15_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2012.02.018"},{"key":"e_1_2_15_160_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-021-05230-1"},{"key":"e_1_2_15_161_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28200"},{"key":"e_1_2_15_162_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0167749"},{"key":"e_1_2_15_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2016.12.014"},{"key":"e_1_2_15_164_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.228"},{"key":"e_1_2_15_165_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26071"}],"container-title":["Annals of Clinical and Translational Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.51776","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T08:10:03Z","timestamp":1692432603000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/acn3.51776"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,6]]},"references-count":164,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1002\/acn3.51776"],"URL":"https:\/\/doi.org\/10.1002\/acn3.51776","archive":["Portico"],"relation":{},"ISSN":["2328-9503","2328-9503"],"issn-type":[{"value":"2328-9503","type":"print"},{"value":"2328-9503","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,6]]},"assertion":[{"value":"2023-02-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}