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CSF total\u2010tau, A\u03b242, and neurofilament light concentrations were investigated using commercially available assays. All affected individuals had T1\u2010weighted volumetric MR images available for analysis of whole and regional brain volumes. Associations between neurogranin, brain volumes, total\u2010tau, A\u03b242, and neurofilament light were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median cerebrospinal fluid neurogranin concentrations were higher in typical and atypical Alzheimer's compared to controls (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001 and <jats:italic>P<\/jats:italic>\u00a0=\u00a00.005). Both neurogranin and total\u2010tau concentrations, but not neurofilament light and A\u03b242, were higher in typical Alzheimer's compared to atypical patients (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.004 and <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03). There were significant differences in the left hippocampus and right and left superior parietal lobules in atypical patients, which were larger (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03) and smaller (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001 and <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), respectively, compared to typical patients. We found no evidence of associations between neurogranin and brain volumes but a strong association with total\u2010tau (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and a weaker association with neurofilament light (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>These results show significant differences in neurogranin and total\u2010tau between typical and atypical patients, which may relate to factors other than disease topography. The differential relationships between neurogranin, total\u2010tau and neurofilament light in the Alzheimer's variants, provide evidence for mechanistically distinct and coupled markers of neurodegeneration.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.518","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T04:09:28Z","timestamp":1515730168000},"page":"162-171","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["CSF neurogranin or tau distinguish typical and atypical Alzheimer disease"],"prefix":"10.1002","volume":"5","author":[{"given":"Henrietta","family":"Wellington","sequence":"first","affiliation":[{"name":"Department of Molecular Neuroscience Institute of Neurology, UCL London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ross W.","family":"Paterson","sequence":"additional","affiliation":[{"name":"Dementia Research Centre Institute of Neurology, Queen 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