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Potential predictors of seizure types were assessed through univariate and binary logistic regression analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>57 (73.1%) patients presented with gelastic seizures at the onset of epilepsy, of whole 39 (68.4%) experienced additional seizure types with a mean latency interval of 4.59\u2009years. Automatism, version, and sGTCs were increasingly common with disease evolution. The intraventricular size of HH was significantly negatively correlated with the disease evolution interval (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.445,<jats:italic>p<\/jats:italic>\u2009=\u20090.009). A significantly higher rate of patients with automatism in the DF\u2010II group relative to the DF\u2010III group was found in both<jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>(<jats:italic>X<\/jats:italic>\u2009=\u20096.07,<jats:italic>p<\/jats:italic>\u2009=\u20090.014) and logistic regression analyses (<jats:italic>B<\/jats:italic>\u2009=\u20093.196,<jats:italic>p<\/jats:italic>\u2009=\u20090.020).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Gelastic seizures are the most common initial seizure type in HH patients, but variable semiologies occur with disease evolution. The intraventricular HH lesion size is an important determinant of epilepsy evolution. DF\u2010II HH lesions contribute to a higher chance of automatism evolution. The present study furthers our understanding of the dynamic organization of the seizure network affected by HH.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.51827","type":"journal-article","created":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T11:40:07Z","timestamp":1687866007000},"page":"1365-1373","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Epilepsy in hypothalamic hamartomas: semiology spectrum and predictor analyses of 78 patients"],"prefix":"10.1002","volume":"10","author":[{"given":"Xiu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Beijing Tian Tan Hospital, Capital Medical University Beijing 100070 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Beijing Tian Tan Hospital, Capital Medical University Beijing 100070 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