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Fox Foundation for Parkinson's Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009307","name":"Parkinson Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009307","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Synucleinopathies\u2010related disorders such as Lewy body dementia (LBD) and isolated\/idiopathic REM sleep behavior disorder (iRBD) have been associated with neuroinflammation. In this study, we examined whether the human leukocyte antigen (<jats:italic>HLA<\/jats:italic>) locus plays a role in iRBD and LBD. In iRBD, <jats:italic>HLA\u2010DRB1<\/jats:italic>*11:01 was the only allele passing FDR correction (OR\u2009=\u20091.57, 95% CI\u2009=\u20091.27\u20131.93, <jats:italic>p<\/jats:italic>\u2009=\u20092.70e\u201005). We also discovered associations between iRBD and <jats:italic>HLA\u2010DRB1<\/jats:italic> 70D (OR\u2009=\u20091.26, 95%CI\u2009=\u20091.12\u20131.41, <jats:italic>p<\/jats:italic>\u2009=\u20098.76e\u201005), 70Q (OR\u2009=\u20090.81, 95%CI\u2009=\u20090.72\u20130.91, <jats:italic>p<\/jats:italic>\u2009=\u20093.65e\u201004) and 71R (OR\u2009=\u20091.21, 95%CI\u2009=\u20091.08\u20131.35, <jats:italic>p<\/jats:italic>\u2009=\u20091.35e\u201003). Position 71 (<jats:italic>p<\/jats:italic><jats:sub>omnibus<\/jats:sub>\u2009=\u20090.00102) and 70 (<jats:italic>p<\/jats:italic><jats:sub>omnibus<\/jats:sub>\u2009=\u20090.00125) were associated with iRBD. Our results suggest that the <jats:italic>HLA<\/jats:italic> locus may have different roles across synucleinopathies.<\/jats:p>","DOI":"10.1002\/acn3.51841","type":"journal-article","created":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T08:16:14Z","timestamp":1688458574000},"page":"1682-1687","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["<scp><i>HLA<\/i><\/scp> in isolated <scp>REM<\/scp> sleep behavior disorder and Lewy body dementia"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3525-4564","authenticated-orcid":false,"given":"Eric","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Human Genetics McGill University  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"The Neuro (Montr\u00e9al Neurological Institute\u2010Hospital) McGill University  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6554-1666","authenticated-orcid":false,"given":"Lynne","family":"Krohn","sequence":"additional","affiliation":[{"name":"Department of Human Genetics McGill University  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"The Neuro (Montr\u00e9al Neurological Institute\u2010Hospital) McGill University  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer A.","family":"Ruskey","sequence":"additional","affiliation":[{"name":"The Neuro (Montr\u00e9al Neurological Institute\u2010Hospital) McGill University  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Neurology and Neurosurgery McGill University  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farnaz","family":"Asayesh","sequence":"additional","affiliation":[{"name":"The Neuro (Montr\u00e9al Neurological Institute\u2010Hospital) McGill University  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Neurology and Neurosurgery McGill University  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Spiegelman","sequence":"additional","affiliation":[{"name":"The Neuro (Montr\u00e9al Neurological Institute\u2010Hospital) McGill University  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Neurology and Neurosurgery McGill University  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zalak","family":"Shah","sequence":"additional","affiliation":[{"name":"Neurodegenerative Diseases Research Unit National Institute of Neurological Disorders and Stroke  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Chia","sequence":"additional","affiliation":[{"name":"Neuromuscular Diseases Research Section National Institute on Aging  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Arnulf","sequence":"additional","affiliation":[{"name":"Sleep Disorders Unit, Piti\u00e9 Salp\u00eatri\u00e8re Hospital Paris Brain Institute and Sorbonne University  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele T. 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