{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:37:38Z","timestamp":1792640258120,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T00:00:00Z","timestamp":1689811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001279","name":"Great Ormond Street Hospital Charity","doi-asserted-by":"publisher","award":["Surgeon\u2010Scientist PhD Programme"],"award-info":[{"award-number":["Surgeon\u2010Scientist PhD Programme"]}],"id":[{"id":"10.13039\/501100001279","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>A greater extent of resection of the temporal portion of the piriform cortex (PC) has been shown to be associated with higher likelihood of seizure freedom in adults undergoing anterior temporal lobe resection (ATLR) for drug\u2010resistant temporal lobe epilepsy (TLE). There have been no such studies in children, therefore this study aimed to investigate this association in a pediatric cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective, neuroimaging cohort study of children with TLE who underwent ATLR between 2012 and 2021 was undertaken. The PC, hippocampal and amygdala volumes were measured on the preoperative and postoperative T1\u2010weighted MRI. Using these volumes, the extent of resection per region was compared between the seizure\u2010free and not seizure\u2010free groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In 50 children (median age 9.5\u2009years) there was no significant difference between the extent of resection of the temporal PC in the seizure\u2010free (median\u2009=\u200950%,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200933\/50) versus not seizure\u2010free (median\u2009=\u200940%,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200917\/50) groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.26). In a sub\u2010group of 19 with ipsilateral hippocampal atrophy (quantitatively defined by ipsilateral\u2010to\u2010contralateral asymmetry), the median extent of temporal PC resection was greater in children who were seizure\u2010free (53%) versus those not seizure\u2010free (19%) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>This is the first study demonstrating that, in children with TLE and hippocampal atrophy, more extensive temporal PC resection is associated with a greater chance of seizure freedom\u2014compatible with an adult series in which 85% of patients had hippocampal sclerosis. In a combined group of children with and without hippocampal atrophy, the extent of PC resection was not associated with seizure outcome, suggesting different epileptogenic networks within this cohort.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.51852","type":"journal-article","created":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T00:33:48Z","timestamp":1689899628000},"page":"1613-1622","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Extent of piriform cortex resection in children with temporal lobe epilepsy"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6422-5853","authenticated-orcid":false,"given":"Rory J.","family":"Piper","sequence":"first","affiliation":[{"name":"Developmental Neurosciences Research and Teaching Department UCL Great Ormond Street Institute of Child Health London UK"},{"name":"Department of Neurosurgery Great Ormond Street Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1064-0541","authenticated-orcid":false,"given":"Debayan","family":"Dasgupta","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology University College London London UK"},{"name":"Victor Horsley Department of Neurosurgery National Hospital for Neurology and Neurosurgery London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6869-5804","authenticated-orcid":false,"given":"Maria H.","family":"Eriksson","sequence":"additional","affiliation":[{"name":"Developmental Neurosciences Research and Teaching Department UCL Great Ormond Street Institute of Child Health London UK"},{"name":"Neuropsychology Great Ormond Street Hospital NHS Trust London UK"},{"name":"Department of Neurology Great Ormond Street Hospital NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1761-5859","authenticated-orcid":false,"given":"Mathilde","family":"Ripart","sequence":"additional","affiliation":[{"name":"Developmental Neurosciences Research and Teaching Department UCL Great Ormond Street Institute of Child Health London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almira","family":"Moosa","sequence":"additional","affiliation":[{"name":"Developmental Neurosciences Research and Teaching Department UCL Great Ormond Street Institute of Child Health London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0053-147X","authenticated-orcid":false,"given":"Aswin","family":"Chari","sequence":"additional","affiliation":[{"name":"Developmental Neurosciences Research and Teaching Department UCL Great Ormond Street Institute of Child Health London UK"},{"name":"Department of Neurosurgery Great Ormond Street Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran K.","family":"Seunarine","sequence":"additional","affiliation":[{"name":"Developmental Neurosciences Research and Teaching Department UCL Great Ormond Street Institute of Child Health London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris A.","family":"Clark","sequence":"additional","affiliation":[{"name":"Developmental Neurosciences Research and Teaching Department UCL Great Ormond Street Institute of Child Health London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1373-0681","authenticated-orcid":false,"given":"John S.","family":"Duncan","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9972-0718","authenticated-orcid":false,"given":"David W.","family":"Carmichael","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8880-8386","authenticated-orcid":false,"given":"Martin M.","family":"Tisdall","sequence":"additional","affiliation":[{"name":"Developmental Neurosciences Research and Teaching Department UCL Great Ormond Street Institute of Child Health London UK"},{"name":"Department of Neurosurgery Great Ormond Street Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5724-1679","authenticated-orcid":false,"given":"Torsten","family":"Baldeweg","sequence":"additional","affiliation":[{"name":"Developmental Neurosciences Research and Teaching Department 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Proposal for a new classification of outcome with respect to epileptic seizures following epilepsy surgery","volume":"42","author":"Wieser HG","year":"2001","journal-title":"Epilepsia"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.02.046"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11548-021-02420-2"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2015.2418298"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.09.015"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac234"},{"key":"e_1_2_10_24_1","article-title":"Optimizing epilepsy surgery","author":"Dasgupta D","year":"2020","journal-title":"ISRCTN Regist"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2022.106971"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.24080"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/02688697.2021.1966385"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.29479"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.591586"}],"container-title":["Annals of Clinical and Translational Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.51852","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,17]],"date-time":"2023-12-17T09:13:56Z","timestamp":1702804436000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/acn3.51852"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,20]]},"references-count":28,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1002\/acn3.51852"],"URL":"https:\/\/doi.org\/10.1002\/acn3.51852","archive":["Portico"],"relation":{},"ISSN":["2328-9503","2328-9503"],"issn-type":[{"value":"2328-9503","type":"print"},{"value":"2328-9503","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,20]]},"assertion":[{"value":"2023-04-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}