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Additionally, electrical conductivity of neural tissue using D\u2010waves above and below the injury was measured to assess correlations between fDWI and D\u2010waves data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eleven minipigs with contusion SCI at T8\u2010T10 level underwent MRI at 3T 4\u2009h. post\u2010SCI. Parameters extracted from region of interest analysis included D<jats:sub>axial<\/jats:sub> from fDWI at injury site, fractional anisotropy and radial diffusivity from DTI above the injury site along with measures of edema length and cord width at injury site from T<jats:sub>2<\/jats:sub>\u2010weighted images. Locomotor recovery was assessed pre\u2010 and weekly post\u2010SCI through porcine thoracic injury behavior scale (PTIBS) and UD were performed pre\u2010 and at 12\u2009weeks of SCI. D\u2010waves latency and amplitude differences were recorded before and immediately after SCI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two groups of pigs were found based on the PTIBS at week 12 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) post\u2010SCI and were labeled \u201cpoor\u201d and \u201cgood\u201d recovery. D\u2010waves amplitude decreased below injury and increased above injury. UD outcomes pre\/post SCI changed significantly. Conventional MRI metrics from T<jats:sub>2<\/jats:sub>\u2010weighted images were significantly correlated with diffusion MRI metrics. D<jats:sub>axial<\/jats:sub> at injury epicenter was diminished by over 50% shortly after SCI, and it differentiated between good and poor locomotor recovery and UD outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Similar to small animal studies, fDWI from acute imaging after SCI is a promising predictor for functional outcomes in large animals.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.51855","type":"journal-article","created":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T05:14:41Z","timestamp":1690521281000},"page":"1647-1661","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Predictive values of spinal cord diffusion <scp>magnetic resonance imaging<\/scp> to characterize outcomes after contusion injury"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8985-3717","authenticated-orcid":false,"given":"Rakib Uddin","family":"Ahmed","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery and Kentucky Spinal Cord Injury Research Center University of Louisville  Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Medina\u2010Aguinaga","sequence":"additional","affiliation":[{"name":"Department of Anatomical Sciences and Neurobiology University of Louisville  Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawns","family":"Adams","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Duke University  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chase A.","family":"Knibbe","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery and Kentucky Spinal Cord Injury Research Center University of Louisville  Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique","family":"Morgan","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery and Kentucky Spinal Cord Injury Research Center University of Louisville  Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Destiny","family":"Gibson","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery and Kentucky Spinal Cord Injury Research Center University of Louisville  Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joo\u2010won","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology Baylor College of Medicine  Houston Texas USA"},{"name":"Department of Psychiatry Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayur","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery and Kentucky Spinal Cord Injury Research Center University of Louisville  Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manpreet","family":"Chopra","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery and Kentucky Spinal Cord Injury Research Center University of Louisville  Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Davison","sequence":"additional","affiliation":[{"name":"Comparative Medicine Research Unit University of Louisville  Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie C.","family":"Sherwood","sequence":"additional","affiliation":[{"name":"Comparative Medicine Research Unit University of Louisville  Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.J.","family":"Negahdar","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Louisville  Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Bert","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Louisville  Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Ugiliweneza","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery and Kentucky Spinal Cord Injury Research Center University of Louisville  Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Hubscher","sequence":"additional","affiliation":[{"name":"Department of Anatomical Sciences and Neurobiology University of Louisville  Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew D.","family":"Budde","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Medical College of Wisconsin  Milwaukee Wisconsin USA"},{"name":"Clement J. 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