{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T03:51:28Z","timestamp":1783050688039,"version":"3.54.6"},"reference-count":53,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T00:00:00Z","timestamp":1690761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Depressive symptoms are frequently reported in patients affected by frontotemporal dementia (FTD). At structural MRI, cortical features of depressed FTD patients have been poorly described. Our objective was to investigate correlations between cortical measures and depression severity in FTD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were obtained from the Frontotemporal Lobar Degeneration Neuroimaging Initiative (FTLDNI) database. We included 98 controls and 92 FTD patients, <jats:italic>n<\/jats:italic>\u2009=\u200938 behavioral variant FTD (bvFTD), <jats:italic>n<\/jats:italic>\u2009=\u200926 non\u2010fluent variant Primary Progressive Aphasia (nfvPPA), and <jats:italic>n<\/jats:italic>\u2009=\u200928 semantic variant Primary Progressive Aphasia (svPPA). Patients underwent clinical and cognitive evaluations, as well as a 3D T1\u2010weighted MRI on a 3 Tesla scanner (Siemens, Trio Tim system). Depression was evaluated by means of Geriatric Depression Scale (GDS). Surface\u2010based analysis was performed on T1\u2010weighted images to evaluate cortical thickness, a measure of gray matter integrity, and local gyrification index (lGI), a quantitative metric of cortical folding.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients affected by svPPA were more depressed than controls at NPI and depression severity at GDS was higher in svPPA and bvFTD. Severity of depression correlated with a decrease in lGI in left precentral and superior frontal gyrus, supramarginal and postcentral gyrus and right precentral, supramarginal, superior parietal and superior frontal gyri. Furthermore, depression severity correlated positively with cortical thickness in the left medial orbitofrontal cortex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>We found that lGI was associated with depressive symptoms over brain regions involved in the pathophysiology of major depressive disorder. This finding provides novel insights into the mechanisms underlying psychiatric symptoms in FTD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.51860","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T10:08:55Z","timestamp":1690798135000},"page":"1704-1713","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cortical signature of depressive symptoms in frontotemporal dementia: A surface\u2010based analysis"],"prefix":"10.1002","volume":"10","author":[{"given":"Alma","family":"Ghirelli","sequence":"first","affiliation":[{"name":"Center for Neurodegenerative Diseases and the Aging Brain, Department of Clinical Research in Neurology University of Bari \u2018Aldo Moro\u2019, \u201cPia\u00a0Fondazione Cardinale G. Panico\u201d  Lecce Italy"},{"name":"Department of Translational Biomedicine and Neuroscience (DiBraiN) University of Bari \u2018Aldo Moro\u2019  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetta","family":"Tafuri","sequence":"additional","affiliation":[{"name":"Center for Neurodegenerative Diseases and the Aging Brain, Department of Clinical Research in Neurology University of Bari \u2018Aldo Moro\u2019, \u201cPia\u00a0Fondazione Cardinale G. Panico\u201d  Lecce Italy"},{"name":"Department of Translational Biomedicine and Neuroscience (DiBraiN) University of Bari \u2018Aldo Moro\u2019  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Urso","sequence":"additional","affiliation":[{"name":"Center for Neurodegenerative Diseases and the Aging Brain, Department of Clinical Research in Neurology University of Bari \u2018Aldo Moro\u2019, \u201cPia\u00a0Fondazione Cardinale G. Panico\u201d  Lecce Italy"},{"name":"Department of Neurosciences, King's College London Institute of Psychiatry, Psychology and Neuroscience  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giammarco","family":"Milella","sequence":"additional","affiliation":[{"name":"Center for Neurodegenerative Diseases and the Aging Brain, Department of Clinical Research in Neurology University of Bari \u2018Aldo Moro\u2019, \u201cPia\u00a0Fondazione Cardinale G. Panico\u201d  Lecce Italy"},{"name":"Department of Translational Biomedicine and Neuroscience (DiBraiN) University of Bari \u2018Aldo Moro\u2019  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"De Blasi","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging Pia Fondazione di Culto e Religione \u201cCard. G. Panico\u201d  Lecce Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Nigro","sequence":"additional","affiliation":[{"name":"Center for Neurodegenerative Diseases and the Aging Brain, Department of Clinical Research in Neurology University of Bari \u2018Aldo Moro\u2019, \u201cPia\u00a0Fondazione Cardinale G. Panico\u201d  Lecce Italy"},{"name":"Institute of Nanotechnology (NANOTEC), National Research Council  Lecce Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0423-3242","authenticated-orcid":false,"given":"Giancarlo","family":"Logroscino","sequence":"additional","affiliation":[{"name":"Center for Neurodegenerative Diseases and the Aging Brain, Department of Clinical Research in Neurology University of Bari \u2018Aldo Moro\u2019, \u201cPia\u00a0Fondazione Cardinale G. Panico\u201d  Lecce Italy"},{"name":"Department of Diagnostic Imaging Pia Fondazione di Culto e Religione \u201cCard. G. Panico\u201d  Lecce Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Frontotemporal Lobar Degeneration Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,31]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2017.75"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr179"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31821103e6"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2010.212225"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000481568"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610220001118"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00127893-200207000-00006"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.23.2.jnp168"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0891988707303603"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2005.072496"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25739"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx101"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0891988720964258"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/286427"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab032"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2007.903576"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2018-320265"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002492"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-200246"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031083"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-021-01247-2"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2018.07.100"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2015.06.014"},{"key":"e_1_2_10_25_1","first-page":"127","article-title":"Cortical folding in patients with bipolar disorder or unipolar depression","volume":"34","author":"Penttil\u00e4 J","year":"2009","journal-title":"J Psychiatry Neurosci"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.12.2.233"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(82)90033-4"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00446"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.444"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.09.050"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jon.12521"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10548-021-00852-2"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10548-022-00919-8"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21095"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2010.00484.x"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2013.12121504"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.neuropsych.12090230"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2014.11.016"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e3283249b34"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2019.04.002"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-015-0691-7"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610213001427"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20923"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.049344"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084914"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt106"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0054-11.2011"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2719"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2013.01.006"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2006.11.006"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2013.4048"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1135626"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/385313a0"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2010.03.012"}],"container-title":["Annals of Clinical and Translational Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.51860","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T20:05:42Z","timestamp":1697486742000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/acn3.51860"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,31]]},"references-count":53,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1002\/acn3.51860"],"URL":"https:\/\/doi.org\/10.1002\/acn3.51860","archive":["Portico"],"relation":{},"ISSN":["2328-9503","2328-9503"],"issn-type":[{"value":"2328-9503","type":"print"},{"value":"2328-9503","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,31]]},"assertion":[{"value":"2023-03-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}