{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:11:16Z","timestamp":1792030276370,"version":"4.4.0"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T00:00:00Z","timestamp":1691452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["Ricerca Corrente"],"award-info":[{"award-number":["Ricerca Corrente"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009281","name":"Fondation Thierry Latran","doi-asserted-by":"publisher","award":["D.2468"],"award-info":[{"award-number":["D.2468"]}],"id":[{"id":"10.13039\/100009281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Beta\u2010synuclein is a promising cerebrospinal fluid and blood biomarker of synaptic damage. Here we analysed its accuracy in the discrimination between sporadic Creutzfeldt\u2013Jakob disease (<jats:italic>n<\/jats:italic>\u2009=\u2009150) and non\u2010prion rapidly progressive dementias (<jats:italic>n<\/jats:italic>\u2009=\u2009106). In cerebrospinal fluid, beta\u2010synuclein performed better than protein 14\u20103\u20103 (AUC 0.95 vs. 0.89) and, to a lesser extent, than total tau (AUC 0.92). Further, the diagnostic value of plasma beta\u2010synuclein (AUC 0.91) outperformed that of plasma tau (AUC 0.79) and neurofilament light chain protein (AUC 0.65) and was comparable to that of cerebrospinal fluid biomarkers. Beta\u2010synuclein might represent the first highly accurate blood biomarker for the diagnosis of sporadic Creutzfeldt\u2013Jakob disease.<\/jats:p>","DOI":"10.1002\/acn3.51873","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T04:50:36Z","timestamp":1691556636000},"page":"1904-1909","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["High diagnostic performance of plasma and cerebrospinal fluid beta\u2010synuclein for sporadic <scp>Creutzfeldt\u2013Jakob<\/scp> disease"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0631-8506","authenticated-orcid":false,"given":"Samir","family":"Abu\u2010Rumeileh","sequence":"first","affiliation":[{"name":"Department of Neurology Martin\u2010Luther\u2010University Halle\u2010Wittenberg  Halle (Saale) Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Halbgebauer","sequence":"additional","affiliation":[{"name":"Department of Neurology Ulm University Hospital  Ulm Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE e.V.)  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