{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T11:45:20Z","timestamp":1776512720334,"version":"3.51.2"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:00:00Z","timestamp":1693180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Examining the size and reactivity of the pupils of traumatic brain injury coma patients is fundamental in the Neuro\u2010intensive care unit (ICU). Pupil parameters on admission predict long\u2010term clinical outcomes. However, little is known about the <jats:italic>dynamics<\/jats:italic> of pupillary parameters and their potential value for outcome prediction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study applied a time\u2010course analysis of pupillary signals (size and photo\u2010reactivity) in acute traumatic brain injury coma patients (<jats:italic>n\u2009=\u200920<\/jats:italic>) to predict outcome at 6\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The time course of pupillary signals was informative in discriminating favorable (F) versus unfavorable (U) outcomes, with the highest correlation within the 1st week notwithstanding pharmacological sedation. Patients with favorable outcome at 6\u2009months showed more consistent in time isochoric and photo\u2010reactive pupils. In contrast, patients with an unfavorable outcome showed more variable measures that tended to stabilize toward pathological values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Time\u2010dependent tracking of pupils' size and reactivity is a promising application for ICU monitoring and long\u2010term prognosis. These findings support the usefulness of automatic tools for the dynamic, quantitative, and objective measurements of pupils.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.51879","type":"journal-article","created":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T05:39:27Z","timestamp":1693287567000},"page":"1854-1862","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Pupillary dynamics predict long\u2010term outcome in a cohort of acute traumatic brain injury coma patients"],"prefix":"10.1002","volume":"10","author":[{"given":"Elena","family":"Monai","sequence":"first","affiliation":[{"name":"Clinica Neurologica University Hospital of Padova  Padova Italy"},{"name":"Department of Neuroscience University of Padova  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Favaretto","sequence":"additional","affiliation":[{"name":"Padova Neuroscience Center (PNC) University of Padova  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Salvalaggio","sequence":"additional","affiliation":[{"name":"Clinica Neurologica University Hospital of Padova  Padova Italy"},{"name":"Department of Neuroscience University of Padova  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Pini","sequence":"additional","affiliation":[{"name":"Padova Neuroscience Center (PNC) University of Padova  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Munari","sequence":"additional","affiliation":[{"name":"Neuro\u2010Intensive Care Unit University Hospital of Padova  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Corbetta","sequence":"additional","affiliation":[{"name":"Clinica Neurologica University Hospital of Padova  Padova Italy"},{"name":"Department of Neuroscience University of Padova  Padova 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