{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:27:29Z","timestamp":1792290449352,"version":"4.4.0"},"reference-count":18,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T00:00:00Z","timestamp":1694476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005339","name":"American Academy of Neurology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR001876"],"award-info":[{"award-number":["UL1TR001876"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006457","name":"Child Neurology Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006457","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To evaluate the role of focal cortical dysplasia co\u2010localization to cortical functional networks in the development of pharmacoresistance. One hundred thirty\u2010six focal cortical dysplasia patients with 3.0\u2009T or 1.5\u2009T MRI were identified from clinical databases at Children's National Hospital. Clinico\u2010radio\u2010pathologic factors and network co\u2010localization were determined. Using binomial logistic regression, limbic network co\u2010localization (odds ratio 4.164 95% confidence interval 1.02\u201317.08,<jats:italic>p<\/jats:italic>\u2009=\u20090.048), and focal to bilateral tonic\u2013clonic seizures (4.82, 1.30\u201318.03,<jats:italic>p<\/jats:italic>\u2009=\u20090.019) predicted pharmacoresistance. These findings provide clinicians with markers to identify patients with focal cortical dysplasia\u2010related epilepsy at high risk of developing pharmacoresistance and should facilitate earlier epilepsy surgical evaluation.<\/jats:p>","DOI":"10.1002\/acn3.51892","type":"journal-article","created":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T05:18:16Z","timestamp":1694582296000},"page":"2161-2165","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Limbic network co\u2010localization predicts pharmacoresistance in dysplasia\u2010related epilepsy"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1410-3487","authenticated-orcid":false,"given":"Nathan T.","family":"Cohen","sequence":"first","affiliation":[{"name":"Center for Neuroscience Research Children's National Hospital, The George Washington University School of Medicine Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phat","family":"Chang","sequence":"additional","affiliation":[{"name":"Center for Neuroscience Research Children's National Hospital, The George Washington University School of Medicine Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8751-0593","authenticated-orcid":false,"given":"Taha","family":"Gholipour","sequence":"additional","affiliation":[{"name":"Center for Neuroscience Research Children's National Hospital, The George Washington University School of Medicine Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chima","family":"Oluigbo","sequence":"additional","affiliation":[{"name":"Center for Neuroscience Research Children's National Hospital, The George Washington University School of Medicine Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. 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