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Inebilizumab is afucosylated and engineered for enhanced affinity to Fc receptor III\u2010A (<jats:italic>FCGR3A<\/jats:italic>) receptors on natural killer cells to maximize antibody\u2010dependent cellular cytotoxicity. Previously, the F allele polymorphism at amino acid 158 of the <jats:italic>FCGR3A<\/jats:italic> gene (F158) was shown to decrease IgG\u2010binding affinity and reduce rituximab (anti\u2010CD20) efficacy for NMOSD attack prevention. In contrast, our current findings from inebilizumab\u2010treated NMOSD patients indicate similar clinical outcomes between those with F158 and V158 allele genotypes.<\/jats:p>","DOI":"10.1002\/acn3.51911","type":"journal-article","created":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T18:38:11Z","timestamp":1696790291000},"page":"2413-2420","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Inebilizumab reduces neuromyelitis optica spectrum disorder risk independent of <scp><i>FCGR3A<\/i><\/scp> polymorphism"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8672-8419","authenticated-orcid":false,"given":"Ho Jin","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Neurology Research Institute and Hospital of National Cancer Center  Goyang South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orhan","family":"Aktas","sequence":"additional","affiliation":[{"name":"Medical Faculty Heinrich Heine University D\u00fcsseldorf  D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina R.","family":"Patterson","sequence":"additional","affiliation":[{"name":"Horizon Therapeutics  Illinois Deerfield USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Schaun","family":"Korff","sequence":"additional","affiliation":[{"name":"Horizon Therapeutics  Illinois Deerfield USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Kunchok","sequence":"additional","affiliation":[{"name":"Department of Neurology Mellen Center for Multiple Sclerosis, Cleveland Clinic  Ohio Cleveland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L.","family":"Bennett","sequence":"additional","affiliation":[{"name":"Department of Neurology, Programs in Neuroscience and Immunology University of Colorado School of Medicine, Anschutz Medical Campus  Colorado Aurora USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian G.","family":"Weinshenker","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Virginia  Virginia Charlottesville USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6378-0070","authenticated-orcid":false,"given":"Friedemann","family":"Paul","sequence":"additional","affiliation":[{"name":"Experimental and Clinical Research Center, Max Delbr\u00fcck Center for Molecular Medicine and Charit\u00e9 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universitat Berlin and Humboldt\u2010Universitat zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans\u2010Peter","family":"Hartung","sequence":"additional","affiliation":[{"name":"Medical Faculty Heinrich Heine University D\u00fcsseldorf  D\u00fcsseldorf Germany"},{"name":"Brain and Mind Centre University of Sydney  New South Wales Sydney Australia"},{"name":"Department of Neurology Medical University Vienna  Vienna Austria"},{"name":"Department of Neurology Palacky University in Olomouc  Olomouc Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Cimbora","sequence":"additional","affiliation":[{"name":"Horizon Therapeutics  Illinois Deerfield USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Smith","sequence":"additional","affiliation":[{"name":"Horizon Therapeutics  Illinois Deerfield USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanette","family":"Mittereder","sequence":"additional","affiliation":[{"name":"Horizon Therapeutics  Illinois Deerfield USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A.","family":"Rees","sequence":"additional","affiliation":[{"name":"Horizon Therapeutics  Illinois Deerfield USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dewei","family":"She","sequence":"additional","affiliation":[{"name":"Horizon Therapeutics  Illinois Deerfield USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7689-2533","authenticated-orcid":false,"given":"Bruce A. 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