{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T17:03:55Z","timestamp":1792343035423,"version":"4.4.0"},"reference-count":74,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T00:00:00Z","timestamp":1697068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170820"],"award-info":[{"award-number":["82170820"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to reveal the role of structural and functional alterations of cingulate gyrus in early cognitive impairment in Type 2 diabetes mellitus (T2DM) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010six T2DM patients and 60 healthy controls (HCs) underwent a neuropsychological assessment and sagittal three\u2010dimensional T1\u2010weighted and resting\u2010state functional MRI. Differences in the cortical thickness of the cingulate cortex and the functional connectivity (FC) of the nine subregions of the cingulate gyrus and the whole brain were compared between T2DM patients and HCs. Correlation analysis was performed between cortex thickness and FC and the participants' clinical\/cognitive variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cortical thickness of the cingulate gyrus was not significantly different between T2DM patients and HCs. However, the T2DM patients showed significantly lower FC between the pregenual ACC (pACC) and the bilateral hippocampus, significantly higher FC between the pACC and bilateral lateral prefrontal cortex (LPFC) and left precentral gyrus, and significantly lower FC between the retrosplenial cortex (RSC) and right cerebellar Crus I. The FC between the pACC and the left hippocampus was negatively correlated with the FC between the pACC and LPFC (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.306, <jats:italic>p<\/jats:italic>\u2009=\u20090.022).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>The pACC and the RSC show dysfunctional connectivity before the appearance of structural abnormalities in T2DM patients. Abnormal FC of the pACC with the bilateral hippocampus and LPFC may imply a neural compensatory mechanism for memory function. These findings provide valuable information and new directions for possible interventions for the T2DM\u2010related cognitive impairment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.51918","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T07:44:28Z","timestamp":1697096668000},"page":"2305-2315","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Structural and functional connectivity alteration patterns of the cingulate gyrus in Type 2 diabetes"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9633-8521","authenticated-orcid":false,"given":"Dongsheng","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of MRI Shaanxi Provincial People's Hospital  Xi'an 710068 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of MRI Shaanxi Provincial People's Hospital  Xi'an 710068 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shasha","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of MRI Shaanxi Provincial People's Hospital  Xi'an 710068 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of MRI Shaanxi Provincial People's Hospital  Xi'an 710068 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weirui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of MRI Shaanxi Provincial People's Hospital  Xi'an 710068 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanting","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of MRI Shaanxi Provincial People's Hospital  Xi'an 710068 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Ai","sequence":"additional","affiliation":[{"name":"Department of Clinical Science Philips Healthcare  Xi'an 710000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of MRI Shaanxi Provincial People's Hospital  Xi'an 710068 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of MRI Shaanxi Provincial People's Hospital  Xi'an 710068 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)01655-5"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70249-2"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/10715762.2018.1529866"},{"issue":"28","key":"e_1_2_10_5_1","first-page":"141","article-title":"The brain as a target organ in type 2 diabetes: exploring the links with cognitive impairment and dementia","volume":"2011","author":"Strachan MW. R D Lawrence Lecture","year":"2010","journal-title":"Diabet Med"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e3181919a48"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-018-0068-2"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68542-5"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-2043"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.06.058"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2014.1004"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2018.05.025"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2016.12.002"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.23283"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2203039119"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2020.03.007"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1169694"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.695210"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101450"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1704"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2018.03.022"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2013.02.010"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0000000000000413"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2016.01.010"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.10.003"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2022.11.006"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2015.03.006"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.10.015"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-64196-0.00015-7"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2018.00021"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.15505"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2014.01.006"},{"key":"e_1_2_10_33_1","first-page":"13","article-title":"Altered functional connectivity density in type 2 diabetes mellitus with and without mild cognitive impairment","volume":"13","author":"Zhang D","year":"2023","journal-title":"Brain Sci"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.21282"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.722861"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2019.101773"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24323"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.11.018"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.32.6.1318"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.09.050"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12021-016-9299-4"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.10.018"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.03.004"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2018.12.012"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291716000702"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2010.12.009"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2017.74"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4443"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abj9195"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/psyg.12592"},{"key":"e_1_2_10_51_1","first-page":"161","article-title":"Executive function predicts the validity of subjective memory complaints in older adults beyond demographic, emotional, and clinical factors","volume":"8","author":"Chao RY","year":"2021","journal-title":"J Prev Alzheimers Dis"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.1967"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3690"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn_a_00810"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci11121652"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.2006.18.6.932"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-014-0744-6"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-804281-6.00012-4"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2022.103100"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2022.119276"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23074"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhaa192"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.1034355"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-76495-3"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.01016"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-018-0534-x"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-67022-5"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22198"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2018.07.257"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.08.039"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.08.065"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13-0519"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.09.041"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2017.01.009"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1080\/1028415X.2019.1609646"}],"container-title":["Annals of Clinical and Translational Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.51918","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,30]],"date-time":"2023-12-30T18:47:14Z","timestamp":1703962034000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/acn3.51918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,12]]},"references-count":74,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1002\/acn3.51918"],"URL":"https:\/\/doi.org\/10.1002\/acn3.51918","archive":["Portico"],"relation":{},"ISSN":["2328-9503","2328-9503"],"issn-type":[{"value":"2328-9503","type":"print"},{"value":"2328-9503","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,12]]},"assertion":[{"value":"2023-05-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}