{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:37:56Z","timestamp":1791995876527,"version":"4.4.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:00:00Z","timestamp":1699833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Interleukin\u201010 (IL\u201010) is a multifunctional cytokine that exerts both pro\u2010 and anti\u2010inflammatory effects on the immune system as well as in the pathogenesis of Guillain\u2013Barr\u00e9 syndrome (GBS). We investigated whether the three common polymorphisms \u20101082 G\/A(rs1800896), \u2010819 C\/T(rs1800871), and \u2010592 C\/A(rs1800872) in the promoter region of IL\u201010 have any influence on the susceptibility, severity, and clinical outcome of GBS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>IL\u201010 promoter polymorphisms were investigated in 152 patients with GBS and 152 healthy controls from Bangladesh using polymerase chain reaction and restriction fragment length polymorphism (PCR\u2010RFLP), and allele\u2010specific oligonucleotide\u2010PCR (ASO\u2010PCR). Haplotype patterns and frequencies were analyzed using Heatmaply R\u2010package, chi\u2010square, and Fisher's exact test. The serum level of IL\u201010 was measured through enzyme\u2010linked immunosorbent assays. <jats:italic>p<\/jats:italic>\u2010values &lt;\u20090.05 were considered statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>IL\u201010 promoter polymorphisms \u20101082 G\/A, \u2010819 C\/T, and \u2010592 C\/A were not associated with GBS susceptibility. The homozygous \u2010819 TT genotype showed a tendency with susceptibility (<jats:italic>p<\/jats:italic>\u2009=\u20090.029; <jats:italic>p<\/jats:italic>c\u2009=\u20090.08) and was prevalent in axonal variants of GBS compared to demyelinating subtypes and controls (<jats:italic>p<\/jats:italic>\u2009=\u20090.042, OR\u2009=\u20098.67, 95% CI\u2009=\u20091.03\u201372.97; <jats:italic>p<\/jats:italic>c\u2009=\u20090.123 and <jats:italic>p<\/jats:italic>\u2009=\u20090.005, OR\u2009=\u20094.2, 95% CI\u2009=\u20091.55\u201311.40; <jats:italic>p<\/jats:italic>c\u2009=\u20090.015, respectively). Haplotype analysis revealed 19 patterns of genotypes and high IL\u201010 expression haplotype combinations (GCC\/GTA, GCC\/ATA, and GCC\/GCA) may have influence on disease severity (<jats:italic>p<\/jats:italic>\u2009=\u20090.026; <jats:italic>p<\/jats:italic>c\u2009=\u20090.078). Serum expression of IL\u201010 was elevated in GBS patients ([GBS, 12.16\u2009\u00b1\u200945.71] vs. [HC, 0.65\u2009\u00b1\u20095.17] pg\/mL; <jats:italic>p<\/jats:italic>\u2009=\u20090.0027) and varied with disease severity ([severe\u2010GBS, 15.25\u2009\u00b1\u200951.72] vs. [mild\u2010GBS, 3.59\u2009\u00b1\u200919.79] pg\/mL, <jats:italic>p<\/jats:italic>\u2009=\u20090.046).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>The \u2010819 TT genotypes influence axonal GBS, and high frequency of IL\u201010 expression haplotype combination with elevated serum IL\u201010 may play an important role in disease severity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.51939","type":"journal-article","created":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T13:24:07Z","timestamp":1699881847000},"page":"133-142","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Interleukin\u201010 promoter polymorphisms and haplotypes in patients with Guillain\u2013Barr\u00e9 syndrome"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1064-9009","authenticated-orcid":false,"given":"Shoma","family":"Hayat","sequence":"first","affiliation":[{"name":"Laboratory of Gut\u2010Brain Axis Infectious Diseases Division (IDD), icddr,b  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6894-0910","authenticated-orcid":false,"given":"Asaduzzaman","family":"Asad","sequence":"additional","affiliation":[{"name":"Laboratory of Gut\u2010Brain Axis Infectious Diseases Division (IDD), icddr,b  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moriam Akter","family":"Munni","sequence":"additional","affiliation":[{"name":"Laboratory of Gut\u2010Brain Axis Infectious Diseases Division (IDD), icddr,b  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2620-1762","authenticated-orcid":false,"given":"Md. Abu Jaher","family":"Nayeem","sequence":"additional","affiliation":[{"name":"Laboratory of Gut\u2010Brain Axis Infectious Diseases Division (IDD), icddr,b  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4587-2239","authenticated-orcid":false,"given":"Md. Golam","family":"Mostafa","sequence":"additional","affiliation":[{"name":"Laboratory of Gut\u2010Brain Axis Infectious Diseases Division (IDD), icddr,b  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Israt","family":"Jahan","sequence":"additional","affiliation":[{"name":"Laboratory of Gut\u2010Brain Axis Infectious Diseases Division (IDD), icddr,b  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Zakir Hossain","family":"Howlader","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology University of Dhaka  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quazi Deen","family":"Mohammad","sequence":"additional","affiliation":[{"name":"National Institute of Neurosciences and Hospital  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0935-8079","authenticated-orcid":false,"given":"Zhahirul","family":"Islam","sequence":"additional","affiliation":[{"name":"Laboratory of Gut\u2010Brain Axis Infectious Diseases Division (IDD), icddr,b  Dhaka 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