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Likewise, acquisition of magnetic resonance imaging to evaluate cerebral atrophy is not straightforward, as prolonged scanning times are less tolerated in this population. Computed tomography (CT) scans can be obtained faster, but poor contrast resolution limits its function for morphometric analysis. We implemented an automated analysis of CT scans to characterize differences across dementia stages in a cross\u2010sectional study of an adult DS cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>CT scans of 98 individuals were analyzed using an automatic algorithm. Voxel\u2010based correlations with clinical dementia stages and AD plasma biomarkers (phosphorylated tau\u2010181 and neurofilament light chain) were identified, and their dysconnectomic patterns delineated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Dementia severity was negatively correlated with gray (GM) and white matter (WM) volumes in temporal lobe regions, including parahippocampal gyri. Dysconnectome analysis revealed an association between WM loss and temporal lobe GM volume reduction. AD biomarkers were negatively associated with GM volume in hippocampal and cingulate gyri.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Our automated algorithm and novel dysconnectomic analysis of CT scans successfully described brain morphometric differences related to AD in adults with DS, providing a new avenue for neuroimaging analysis in populations for whom magnetic resonance imaging is difficult to obtain.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.51940","type":"journal-article","created":{"date-parts":[[2023,12,30]],"date-time":"2023-12-30T06:04:57Z","timestamp":1703916297000},"page":"143-155","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Voxel\u2010based dysconnectomic brain morphometry with computed tomography in Down syndrome"],"prefix":"10.1002","volume":"11","author":[{"given":"Beatriz","family":"S\u00e1nchez\u2010Moreno","sequence":"first","affiliation":[{"name":"Adult Down Syndrome Unit, Department of Internal Medicine Hospital Universitario de La Princesa  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2122-9771","authenticated-orcid":false,"given":"Linda","family":"Zhang","sequence":"additional","affiliation":[{"name":"Alzheimer Disease Research Unit CIEN Foundation, Queen Sofia Foundation Alzheimer Centre  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gloria","family":"Mateo","sequence":"additional","affiliation":[{"name":"Adult Down Syndrome Unit, Department of Internal Medicine Hospital Universitario de La Princesa  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Moldenhauer","sequence":"additional","affiliation":[{"name":"Adult Down Syndrome Unit, 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